{id:39401,date:2025-03-18T14:31:03,date_gmt:2025-03-18T14:31:03,guid:{rendered:https:\/\/www.hunimed.eu\/news\/cancro-e-cellule-dendritiche-eduardo-bonavita-si-aggiudica-un-finanziamento-da-worldwide-cancer-research\/},modified:2025-03-18T14:31:03,modified_gmt:2025-03-18T14:31:03,slug:cancro-e-cellule-dendritiche-eduardo-bonavita-si-aggiudica-un-finanziamento-da-worldwide-cancer-research,status:publish,type:post,link:https:\/\/www.hunimed.eu\/it\/news\/cancro-e-cellule-dendritiche-eduardo-bonavita-si-aggiudica-un-finanziamento-da-worldwide-cancer-research\/,title:{rendered:Cancro e cellule dendritiche: Eduardo Bonavita si aggiudica un finanziamento da Worldwide Cancer Research},content:{rendered:\n<p>Le immunoterapie stanno rivoluzionando il trattamento tumori solidi, aumentando in modo sostanziale la sopravvivenza e riducendo il tasso di recidive. Queste terapie funzionano togliendo il freno \u2013 i cosiddetti checkpoint immunitari \u2013 ai linfociti T, che possono cos\u00ec attaccare ed eliminare con maggiore efficacia le cellule tumorali. Purtroppo per\u00f2 non tutti i pazienti rispondono allo stesso modo alle immunoterapie: comprendere perch\u00e9 e sviluppare nuove strategie terapeutiche \u00e8 uno degli obiettivi pi\u00f9 urgenti della ricerca oncologica.<\/p>\n\n\n\n<p>Un nuovo progetto guidato da <strong><a href=\https:\/\/www.hunimed.eu\/member\/eduardo-bonavita\/\>Eduardo Bonavita<\/a><\/strong> \u2013 responsabile del laboratorio di Oncoimmunologia Cellulare e Molecolare di °µÍø½ûÇø e Assistant Professor di °µÍø½ûÇø University \u2013 si concentrer\u00e0 sullo studio delle cellule dendritiche, che agiscono a monte della risposta linfocitaria e la cui compromissione potrebbe spiegare l\u2019inefficacia delle immunoterapie: sono infatti queste cellule che indicano ai linfociti la minaccia da combattere; senza di loro i linfociti T, con o senza checkpoint immunitari attivati, non sono in grado di combattere il tumore.<\/p>\n\n\n\n<p>\u201cStudiare le cellule dendritiche \u00e8 una sfida complessa dal punto di vista scientifico e tecnologico, perch\u00e9 sono poco numerose e difficili da coltivare in vitro. Ma sappiamo che svolgono un ruolo essenziale nell&#8217;espansione dei linfociti T specifici per il tumore. Da questo punto di vista, le attuali immunoterapie che prendono di mira i \u2018freni immunitari\u2019 dei linfociti T non possono risultare efficaci se a monte viene compromessa l\u2019azione delle cellule dendritiche,\u201d spiega Eduardo Bonavita. \u201cEcco perch\u00e9 vogliamo capire se queste ultime funzionano correttamente nei pazienti resistenti alle immunoterapie, e vogliamo sviluppare strategie mirate per riattivarle.\u201d<\/p>\n\n\n\n<p>L\u2019ambizioso progetto si \u00e8 aggiudicato un finanziamento da <strong><a href=\https:\/\/www.worldwidecancerresearch.org\/\>Worldwide Cancer Research<\/a><\/strong>,\u00a0un\u2019organizzazione con sede nel Regno Unito che sostiene studi sui tumori a livello globale. &#8220;Worldwide Cancer Research finanzia progetti rivoluzionari che potrebbero aprire la strada a nuove cure per il cancro. Siamo felici di supportare il lavoro innovativo di Eduardo Bonavita, che mira a migliorare l\u2019efficacia dell\u2019immunoterapia oncologica,\u201d afferma Nicola Hawkes, responsabile del programma di finanziamento. \u201c\u00c8 grazie a ricerche fondamentali come questa se potremo avvicinarci a un futuro in cui nessuna vita sar\u00e0 pi\u00f9 spezzata dal cancro.\u201d<\/p>\n\n\n\n<p>Utilizzando tecnologie all\u2019avanguardia, tra cui modelli preclinici di nuova generazione, analisi multi-omiche e tecniche avanzate di citometria in grado di isolare e analizzare le cellule dendritiche, il team guidato da Bonavita cercher\u00e0 di comprendere i meccanismi che regolano l&#8217;attivazione delle cellule dendritiche all&#8217;interno del microambiente tumorale, con particolare attenzione al fattore di trascrizione Bhlhe40, potenzialmente coinvolto nell\u2019orchestrazione della risposta immunitaria anti-tumorale.<\/p>\n\n\n\n<p>L\u2019obiettivo finale? Ristabilire e potenziare l\u2019attivit\u00e0 delle cellule dendritiche contro il cancro.<\/p>\n,protected:false},excerpt:{rendered:<p>Le immunoterapie stanno rivoluzionando il trattamento tumori solidi, aumentando in modo sostanziale la sopravvivenza e riducendo il tasso di recidive. Queste terapie funzionano togliendo il freno \u2013 i cosiddetti checkpoint immunitari \u2013 ai linfociti T, che possono cos\u00ec attaccare ed eliminare con maggiore efficacia le cellule tumorali. Purtroppo per\u00f2 non tutti i pazienti rispondono allo [&hellip;]<\/p>\n,protected:false},author:16,featured_media:28005,comment_status:open,ping_status:open,sticky:false,template:,format:standard,meta:{_acf_changed:false,_kad_blocks_custom_css:,_kad_blocks_head_custom_js:,_kad_blocks_body_custom_js:,_kad_blocks_footer_custom_js:,footnotes:},categories:[2025],tags:[],class_list:[post-39401,post,type-post,status-publish,format-standard,has-post-thumbnail,hentry,category-scienze-mediche-3-2],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cancro e cellule dendritiche: Eduardo Bonavita si aggiudica un finanziamento da Worldwide Cancer Research - Hunimed<\/title>\n<meta name=\description\ content=\Le immunoterapie stanno rivoluzionando il trattamento tumori solidi, aumentando in modo sostanziale la sopravvivenza e riducendo il tasso di recidive.\ \/>\n<meta name=\robots\ content=\index, 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