{id:37755,date:2021-12-15T16:14:05,date_gmt:2021-12-15T16:14:05,guid:{rendered:https:\/\/www.hunimed.eu\/news\/pubblicato-un-nuovo-studio-humanitas-sulle-patologie-mieloproliferative\/},modified:2021-12-15T16:14:05,modified_gmt:2021-12-15T16:14:05,slug:pubblicato-un-nuovo-studio-humanitas-sulle-patologie-mieloproliferative,status:publish,type:post,link:https:\/\/www.hunimed.eu\/it\/news\/pubblicato-un-nuovo-studio-humanitas-sulle-patologie-mieloproliferative\/,title:{rendered:Pubblicato un nuovo studio °µÍø½ûÇø sulle patologie mieloproliferative},content:{rendered:<p>\u00c8 a firma<strong>\u00a0°µÍø½ûÇø<\/strong>\u00a0lo\u00a0studio\u00a0pubblicato su\u00a0<em>Stem Cell Report\u00a0<\/em>sulle\u00a0<strong>malattie mieloproliferative croniche<\/strong>: una Ricerca che<strong>\u00a0<\/strong>si \u00e8 focalizzata sulla presenza nelle cellule del sangue e del midollo osseo della\u00a0<strong>mutazione V617F nel gene JAK2<\/strong>.<\/p>\n<p>Lo studio \u00e8 stato condotto dall\u2019\u00e9quipe della dottoressa\u00a0<strong>Francesca Ficara<\/strong>, composta da specialisti di °µÍø½ûÇø e di altri Istituti, tra cui la dottoressa\u00a0<strong>Laura Crisafulli<\/strong>\u00a0e la dottoressa\u00a0<strong>Sharon Muggeo\u00a0<\/strong>e parzialmente finanziato da AIRC-Fondazione Cariplo e Fondazione Damiano per l\u2019Ematologia. La Ricerca si \u00e8 svolta in °µÍø½ûÇø dal gruppo del\u00a0<strong>CNR-IRGB<\/strong>, con la collaborazione di altre unit\u00e0 °µÍø½ûÇø: <strong>Genomic Unit<\/strong>,\u00a0<strong>Flow Cytometry Core<\/strong>,\u00a0<strong>Biostatistic Unit<\/strong>\u00a0e\u00a0<strong>Cancer Center<\/strong>\u00a0con il gruppo del professor<strong>\u00a0<a href=\https:\/\/www.hunimed.eu\/it\/member\/matteo-giovanni-della-porta\/\>Matteo Della Porta<\/a><\/strong>.<\/p>\n<h3><strong>I risultati dello studio<\/strong><\/h3>\n<p>La Ricerca ha evidenziato il ruolo della\u00a0<strong>proteina Pbx1<\/strong>\u00a0nelle malattie mieloproliferative croniche, abitualmente deputata alla regolazione della\u00a0<strong>funzione delle cellule staminali nel sangue<\/strong>, proteina che regola la formazione di\u00a0<strong>globuli rossi e piastrine\u00a0<\/strong>che, in caso di\u00a0<strong>mutazione a carico del gene JAK2,<\/strong>\u00a0risulta fuori controllo. Dallo studio emerge come impedire l\u2019evoluzione della patologia o determinarne la regressione sia possibile\u00a0<strong>rimuovendo la proteina Pbx1<\/strong>. Una scoperta che ha permesso di identificare un nuovo possibile\u00a0<strong>bersaglio terapeutico<\/strong>: gli studi sulle malattie mieloproliferative proseguiranno dunque in questo senso, valutando se Pbx1 o altre proteine regolate da Pbx1, possano essere bloccate mediante<strong>\u00a0azione farmacologica\u00a0<\/strong>e migliorare cos\u00ec la condizione clinica del paziente.<\/p>\n<h3><strong>L\u2019importanza della Ricerca per la cura delle malattie mieloproliferative croniche<\/strong><\/h3>\n<p>La<strong>\u00a0policitemia vera<\/strong>, la\u00a0<strong>trombocitemia essenziale\u00a0<\/strong>e le altre patologie mieloproliferative croniche si associano a una\u00a0<strong>produzione abnorme di globuli rossi, piastrine e\/o granulociti<\/strong>. Una condizione che mina sensibilmente la\u00a0<strong>qualit\u00e0 della vita e la salute\u00a0<\/strong>dei pazienti interessati. Nonostante i progressi terapeutici degli ultimi anni, in una percentuale di pazienti il trattamento standard non \u00e8 in grado di garantire un controllo ottimale della malattia. Per questo motivo, identificare<strong>\u00a0nuovi bersagli terapeutici<\/strong>\u00a0grazie alla Ricerca scientifica \u00e8 di fondamentale importanza.<\/p>\n<p><a class=\button secondary\ href=\https:\/\/www.cell.com\/stem-cell-reports\/issue?pii=S2213-6711(20)X0012-9#\>Leggi l&#8217;articolo su Stem Cell Report<\/a><\/p>\n,protected:false},excerpt:{rendered:<p>\u00c8 a firma\u00a0°µÍø½ûÇø\u00a0lo\u00a0studio\u00a0pubblicato su\u00a0Stem Cell Report\u00a0sulle\u00a0malattie mieloproliferative croniche: una Ricerca che\u00a0si \u00e8 focalizzata sulla presenza nelle cellule del sangue e del midollo osseo della\u00a0mutazione V617F nel gene JAK2. Lo studio \u00e8 stato condotto dall\u2019\u00e9quipe della dottoressa\u00a0Francesca Ficara, composta da specialisti di °µÍø½ûÇø e di altri Istituti, tra cui la dottoressa\u00a0Laura Crisafulli\u00a0e la dottoressa\u00a0Sharon Muggeo\u00a0e parzialmente [&hellip;]<\/p>\n,protected:false},author:16,featured_media:4381,comment_status:open,ping_status:open,sticky:false,template:,format:standard,meta:{_acf_changed:false,_kad_blocks_custom_css:,_kad_blocks_head_custom_js:,_kad_blocks_body_custom_js:,_kad_blocks_footer_custom_js:,footnotes:},categories:[401,2025],tags:[],class_list:[post-37755,post,type-post,status-publish,format-standard,has-post-thumbnail,hentry,category-mondo-humanitas,category-scienze-mediche-3-2],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pubblicato un nuovo studio °µÍø½ûÇø sulle patologie mieloproliferative - Hunimed<\/title>\n<meta name=\description\ content=\\u00c8 a 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