{id:37225,date:2017-11-07T00:00:00,date_gmt:2017-11-07T00:00:00,guid:{rendered:https:\/\/www.hunimed.eu\/news\/il-1r8-una-nuova-arma-contro-tumori-su-nature-lo-studio-di-humanitas\/},modified:2025-10-14T02:45:47,modified_gmt:2025-10-14T02:45:47,slug:il-1r8-una-nuova-arma-contro-tumori-su-nature-lo-studio-di-humanitas,status:publish,type:post,link:https:\/\/www.hunimed.eu\/it\/news\/il-1r8-una-nuova-arma-contro-tumori-su-nature-lo-studio-di-humanitas\/,title:{rendered:IL-1R8, una nuova arma contro i tumori: su Nature lo studio di °µÍø½ûÇø},content:{rendered:<p><span style=\font-weight: 400;\>La nuova speranza contro i tumori si chiama <\/span><b>IL-1R8<\/b><span style=\font-weight: 400;\>. Si tratta di un <strong>freno dell\u2019immunit\u00e0<\/strong> coinvolto nello sviluppo tumorale.\u00a0<\/span><span style=\font-weight: 400;\>Secondo lo studio, pubblicato dalla prestigiosa rivista \u201c<a href=\https:\/\/www.nature.com\/articles\/nature24293\ target=\_blank\ rel=\noopener noreferrer\><strong>Nature<\/strong><\/a>\u201d, diretto e coordinato da °µÍø½ûÇø e finanziato da<strong> <a href=\http:\/\/www.airc.it\/?istituzionale=true\ target=\_blank\ rel=\noopener noreferrer\>AIRC<\/a><\/strong>,\u00a0<\/span><span style=\font-weight: 400;\>IL-1R8 ha dimostrato un\u2019efficace azione di <strong>mediatore della resistenza contro tumori e metastasi<\/strong>, in particolare quelli <strong>al fegato e al polmone<\/strong>, bloccandone di fatto lo sviluppo.<\/span><\/p>\n<p><span style=\font-weight: 400;\><em>Corresponding author<\/em>\u00a0dello studio il\u00a0<strong><a href=\https:\/\/www.hunimed.eu\/professors\/alberto-mantovani\/\>prof. Alberto Mantovani<\/a><\/strong><a href=\https:\/\/www.hunimed.eu\/professors\/alberto-mantovani\/\>,<\/a> Direttore Scientifico di\u00a0°µÍø½ûÇø e docente di °µÍø½ûÇø University,<a href=\http:\/\/www.humanitas-research.org\/2015\/06\/06\/mantovani-alberto\/\ target=\_blank\ rel=\noopener noreferrer\>\u00a0<\/a><\/span><span style=\font-weight: 400;\>e la <a href=\https:\/\/www.hunimed.eu\/it\/professori\/cecilia-garlanda\/\><strong>prof. Cecilia Garlanda<\/strong><\/a>, <em>Principal Investigator<\/em> del Laboratorio di Immunopatologia sperimentale di °µÍø½ûÇø e docente di °µÍø½ûÇø University.\u00a0<\/span><span style=\font-weight: 400;\><strong>Prima autrice<\/strong> dello studio \u00e8 invece la dottoressa <strong>Martina Molgora<\/strong>, ricercatrice di °µÍø½ûÇø e studentessa di<strong> <a href=\https:\/\/www.hunimed.eu\/courses\/phd-molecular-experimental-medicine\/\>dottorato di °µÍø½ûÇø University<\/a><\/strong>.\u00a0<\/span><span style=\font-weight: 400;\>Tra le ricercatrici coinvolte vi sono anche la prof. Angela Santoni e il suo gruppo dell\u2019Universit\u00e0 \u201cLa Sapienza\u201d di Roma<\/span><span style=\font-weight: 400;\>.<\/span><\/p>\n<h3>Come agisce questo freno?<img loading=\lazy\ decoding=\async\ class=\alignnone size-full wp-image-33670\ src=\https:\/\/www.hunimed.eu\/wp-content\/uploads\/2025\/08\/iStock-635475308.jpg\ alt=\\ width=\1254\ height=\836\ \/><\/h3>\n<p><span style=\font-weight: 400;\>Il nostro sistema immunitario funziona come un\u2019automobile: n<\/span><span style=\font-weight: 400;\>ecessita di acceleratori, ma anche di freni (chiamati <\/span><b>checkpoint<\/b><span style=\font-weight: 400;\>), che le consentono di rallentare e, quando \u00e8 il caso, fermarsi.\u00a0<\/span><span style=\font-weight: 400;\>Spesso, per\u00f2, il tumore riesce a utilizzare questi freni a proprio vantaggio, disattivando le nostre difese e crescendo indisturbato.<\/span><\/p>\n<p><span style=\font-weight: 400;\>La chiave del successo sta nell\u2019eliminare questi freni, cos\u00ec da consentire al nostro sistema immunitario di combattere i tumori.<\/span><br \/>\n \u00c8 il caso, ad esempio,\u00a0di freni come CTLA4 e PD-1\/PD-L1 gi\u00e0 usati nelle <strong>terapie immunologiche<\/strong> contro il melanoma e altri tumori,\u00a0da cui per\u00f2 traggono beneficio solo il 20-40% dei pazienti.<\/p>\n<h3>Nuove prospettive di cura?<\/h3>\n<p><span style=\font-weight: 400;\>La scoperta di IL-1R8 inaugura una nuova e promettente stagione nell\u2019uso sempre pi\u00f9 efficace di armi immunologiche contro i diversi tumori.<\/span><\/p>\n<p><span style=\font-weight: 400;\>In base ai risultati dello studio, gli scienziati hanno osservato che, se si riesce a identificare la sua azione \u201cfrenante\u201d delle nostre difese immunitarie (in particolare delle cosiddette cellule <\/span><strong><i>Natural Killer<\/i><\/strong><span style=\font-weight: 400;\>) e la si inibisce, allora le stesse cellule NK si attivano a difesa degli organi colpiti da cancro e metastasi.<\/span><\/p>\n<p>Leggi<a href=\https:\/\/www.nature.com\/articles\/nature24293\ target=\_blank\ rel=\noopener noreferrer\> l&#8217;articolo originale su Nature.<\/a><\/p>\n<p>Leggi <a href=\https:\/\/www.hunimed.eu\/it\/tag\/alberto-mantovani\/\>altri articoli del prof. Mantovani<\/a>.<\/p>\n,protected:false},excerpt:{rendered:<p>La nuova speranza contro i tumori si chiama IL-1R8. Si tratta di un freno dell\u2019immunit\u00e0 coinvolto nello sviluppo tumorale.\u00a0Secondo lo studio, pubblicato dalla prestigiosa rivista \u201cNature\u201d, diretto e coordinato da °µÍø½ûÇø e finanziato da AIRC,\u00a0IL-1R8 ha dimostrato un\u2019efficace azione di mediatore della resistenza contro tumori e metastasi, in particolare quelli al fegato e al polmone, [&hellip;]<\/p>\n,protected:false},author:1,featured_media:16705,comment_status:open,ping_status:open,sticky:false,template:,format:standard,meta:{_acf_changed:false,_kad_blocks_custom_css:,_kad_blocks_head_custom_js:,_kad_blocks_body_custom_js:,_kad_blocks_footer_custom_js:,footnotes:},categories:[2026,2025,2385],tags:[414,2596,2557,2597,425,1639,2429,2592,2598,2494,1659,1660,2599,2586,2521],class_list:[post-37225,post,type-post,status-publish,format-standard,has-post-thumbnail,hentry,category-didattica-4-2,category-scienze-mediche-3-2,category-tutti-5,tag-alberto-mantovani,tag-cecilia-garlanda-5,tag-cultura-scientifica-5,tag-dottorato-mem-5,tag-humanitas-university,tag-hunimed-2,tag-immunita-5,tag-immunologia-5,tag-natural-killer-5,tag-oncologia-8,tag-phd-2,tag-phd-in-medicine-2,tag-phd-mem-5,tag-sistema-immunitario-5,tag-tumori-5],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IL-1R8, una nuova arma contro i tumori: su Nature lo studio di °µÍø½ûÇø - Hunimed<\/title>\n<meta name=\description\ content=\La nuova speranza contro i tumori si chiama IL-1R8. 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