{id:37169,date:2017-04-06T00:00:00,date_gmt:2017-04-06T00:00:00,guid:{rendered:https:\/\/www.hunimed.eu\/news\/infiammazioni-e-disabilita-cognitive-esiste-un-legame\/},modified:2025-10-14T02:44:52,modified_gmt:2025-10-14T02:44:52,slug:infiammazioni-e-disabilita-cognitive-esiste-un-legame,status:publish,type:post,link:https:\/\/www.hunimed.eu\/it\/news\/infiammazioni-e-disabilita-cognitive-esiste-un-legame\/,title:{rendered:Infiammazioni e disabilit\u00e0 cognitive: esiste un legame?},content:{rendered:<p>Secondo numerosi studi scientifici, esiste una correlazione tra i <strong>difetti genetici nella produzione di proteine<\/strong> a livello delle sinapsi e i\u00a0disturbi del neurosviluppo\u00a0caratterizzati da <strong>deficit cognitivi<\/strong>. Tuttavia, una percentuale di tali patologie non presenta evidenti cause genetiche.<\/p>\n<p>Ora, uno\u00a0studio\u00a0pubblicato sulla prestigiosa rivista eLife e condotto da Istituto Clinico <strong>°µÍø½ûÇø<\/strong> e l&#8217;<strong>Istituto di Neuroscienze del <a href=\http:\/\/www.in.cnr.it\/index.php\/en\/\ target=\_blank\ rel=\noopener noreferrer\>CNR<\/a><\/strong>, in collaborazione con l\u2019<strong>Universidad Miguel Hern\u00e1ndez<\/strong>, lnstituto de Neurociencias, per la prima volta \u00e8 riuscito a identificare una relazione tra alti livelli di\u00a0<strong>infiammazione<\/strong>\u00a0e un\u2019aumentata espressione della\u00a0<strong>proteina MeCP2<\/strong>.<\/p>\n<p>La proteina in questione appare coinvolta nell\u2019insorgenza di disturbi dello\u00a0sviluppo neurologico infantile\u00a0caratterizzati da gravi disabilit\u00e0 fisiche e mentali nonch\u00e9 in patologie come la <strong>sindrome di Rett<\/strong> e la <strong>sindrome da duplicazione di MeCP2<\/strong>.<\/p>\n<h3>Come agisce l\u2019infiammazione nello sviluppo della disabilit\u00e0 cognitiva?<\/h3>\n<p><img loading=\lazy\ decoding=\async\ class=\aligncenter wp-image-29727 size-full\ src=\https:\/\/www.hunimed.eu\/wp-content\/uploads\/2025\/08\/iStock-482546476.jpg\ alt=\\ width=\1946\ height=\1541\ \/><\/p>\n<p>&nbsp;<\/p>\n<p>Ne abbiamo parlato con la <strong><a href=\https:\/\/www.hunimed.eu\/it\/professori\/michela-matteoli\/\>Professoressa\u00a0Michela Matteoli<\/a><\/strong>, Responsabile di °µÍø½ûÇø Neuro Center, Direttore dell\u2019Istituto di Neuroscienze del CNR e docente di °µÍø½ûÇø University, e con il <a href=\http:\/\/www.humanitas-research.org\/2015\/06\/06\/mantovani-alberto\/\>Professor\u00a0Alberto Mantovani<\/a>, Direttore Scientifico presso l\u2019Istituto Clinico °µÍø½ûÇø e Docente di °µÍø½ûÇø University, fra gli autori dello studio.<\/p>\n<p>Si \u00e8 riusciti a dimostrare che un\u2019eccessiva infiammazione aumenta i livelli di MeCP2, una proteina coinvolta nelle malattie del neurosviluppo. Grazie all\u2019azione di un farmaco antagonista del recettore dell\u2019interleuchina-1 beta, siamo riusciti a bloccare una delle molecole chiave dell\u2019infiammazione, correggendo i livelli di MeCP2\u00a0e normalizzando i difetti di apprendimento. Si tratta di una scoperta effettuata in laboratorio che, al momento, non pu\u00f2 ancora vantare evidenze cliniche.<\/p>\n<h3>Quale legame esiste tra infiammazione e sinaptopatie?<\/h3>\n<p>Per comprendere meglio l\u2019origine delle disabilit\u00e0 cognitive, i ricercatori hanno concentrato la loro attenzione sull\u2019infiammazione\u00a0quale uno dei principali fattori noti per la capacit\u00e0 di modificare rischio e gravit\u00e0 dei disturbi dello sviluppo. In particolare, i ricercatori hanno voluto capire se e come l\u2019infiammazione colpisse le sinapsi causando <strong>sinaptopatie<\/strong>, cio\u00e8\u00a0malattie delle sinapsi, termine conosciuto per indicare le malattie del neurosviluppo. Lo sviluppo di sinaptopatie \u00e8 correlato a un\u2019alterata <strong>attivit\u00e0 di controllo delle sinapsi su tutte le abilit\u00e0<\/strong>, incluse quelle cognitive, come l\u2019apprendimento, l\u2019attenzione, la percezione ecc.<\/p>\n<p>Questa importante scoperta potrebbe consentire di <strong>arginare le disabilit\u00e0 cognitive<\/strong>, migliorando la qualit\u00e0 di vita nei pazienti affetti da malattie autoinfiammatorie caratterizzate da deficit cognitivi.<\/p>\n,protected:false},excerpt:{rendered:<p>Secondo numerosi studi scientifici, esiste una correlazione tra i difetti genetici nella produzione di proteine a livello delle sinapsi e i\u00a0disturbi del neurosviluppo\u00a0caratterizzati da deficit cognitivi. Tuttavia, una percentuale di tali patologie non presenta evidenti cause genetiche. Ora, uno\u00a0studio\u00a0pubblicato sulla prestigiosa rivista eLife e condotto da Istituto Clinico °µÍø½ûÇø e l&#8217;Istituto di Neuroscienze del CNR, [&hellip;]<\/p>\n,protected:false},author:1,featured_media:15494,comment_status:open,ping_status:open,sticky:false,template:,format:standard,meta:{_acf_changed:false,_kad_blocks_custom_css:,_kad_blocks_head_custom_js:,_kad_blocks_body_custom_js:,_kad_blocks_footer_custom_js:,footnotes:},categories:[2026,1674,401,2025,2385],tags:[2515,1645,1656,2443,2405],class_list:[post-37169,post,type-post,status-publish,format-standard,has-post-thumbnail,hentry,category-didattica-4-2,category-education-2,category-mondo-humanitas,category-scienze-mediche-3-2,category-tutti-5,tag-cnr-5,tag-humanitas-2,tag-neuroscience-2,tag-neuroscienze-5,tag-ricerca-5],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Infiammazioni e disabilit\u00e0 cognitive: esiste un 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