{id:147867,date:2026-07-09T10:18:54,date_gmt:2026-07-09T10:18:54,guid:{rendered:https:\/\/www.hunimed.eu\/?page_id=147867},modified:2026-07-30T09:48:38,modified_gmt:2026-07-30T09:48:38,slug:biophysics-research-center,status:publish,type:page,link:https:\/\/www.hunimed.eu\/it\/biophysics-research-center\/,title:{rendered:Biophysics Research Center},content:{rendered:<style>.kadence-column147867_ee0d26-c9 > .kt-inside-inner-col{padding-bottom:32px;}.kadence-column147867_ee0d26-c9 > .kt-inside-inner-col,.kadence-column147867_ee0d26-c9 > .kt-inside-inner-col:before{border-top-left-radius:0px;border-top-right-radius:0px;border-bottom-right-radius:0px;border-bottom-left-radius:0px;}.kadence-column147867_ee0d26-c9 > .kt-inside-inner-col{column-gap:var(--global-kb-gap-sm, 1rem);}.kadence-column147867_ee0d26-c9 > .kt-inside-inner-col{flex-direction:column;}.kadence-column147867_ee0d26-c9 > .kt-inside-inner-col > .aligncenter{width:100%;}.kadence-column147867_ee0d26-c9 > 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.wp-block-kadence-advancedheading.kt-adv-heading147867_fe4c39-be[data-kb-block=\kb-adv-heading147867_fe4c39-be\]{margin-bottom:0px;font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading147867_fe4c39-be mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading147867_fe4c39-be[data-kb-block=\kb-adv-heading147867_fe4c39-be\] mark.kt-highlight{font-style:normal;background-image:linear-gradient(90deg,rgb(0,121,83) 0%,rgb(0,223,153) 84%);-webkit-background-clip:text;background-clip:text;-webkit-text-fill-color:transparent;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading147867_fe4c39-be img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading147867_fe4c39-be[data-kb-block=\kb-adv-heading147867_fe4c39-be\] img.kb-inline-image{width:150px;vertical-align:baseline;}@media all and (max-width: 767px){.wp-block-kadence-advancedheading.kt-adv-heading147867_fe4c39-be, .wp-block-kadence-advancedheading.kt-adv-heading147867_fe4c39-be[data-kb-block=\kb-adv-heading147867_fe4c39-be\]{font-size:var(--global-kb-font-size-lg, 2rem);}}<\/style>\n<h1 class=\kt-adv-heading147867_fe4c39-be wp-block-kadence-advancedheading has-black-color has-text-color\ data-kb-block=\kb-adv-heading147867_fe4c39-be\><mark true=\true\ class=\kt-highlight\>Biophysics Research<\/mark> Center<\/h1>\n<\/div><\/div>\n\n<\/div><\/div>\n\n\n\n\n<div class=\wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-8f761849 wp-block-group-is-layout-flex\>\n<p class=\has-grey-dark-color has-text-color has-link-color has-m-font-size wp-elements-88d0c05253c2cc0a1616f257a7920bb4 wp-block-paragraph\>La biofisica applica i principi e i metodi della fisica per comprendere e caratterizzare i sistemi viventi a diverse scale, dalle molecole e cellule ai tessuti, agli organi e al corpo umano. Situata all\u2019interfaccia tra fisica, ingegneria, biologia e medicina, offre strumenti sempre pi\u00f9 precisi per misurare la fisiologia e la malattia, sviluppare nuove tecnologie e tradurre le scoperte fondamentali in innovazione biomedica.<\/p>\n<\/div>\n\n\n\n<div class=\wp-block-group alignfull is-style-s-section-padding\><div class=\wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\>\n<hr class=\wp-block-separator alignfull has-alpha-channel-opacity is-style-thin\\/>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\wp-block-group\><div class=\wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\>\n<div class=\wp-block-group\><div class=\wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\>\n<h2 id=\openday\ class=\wp-block-heading\>Il Centro<\/h2>\n\n\n\n<p class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-c22c4cc98c2d7fc91159f4871328bebe wp-block-paragraph\>°µÍø½ûÇø University \u00e8 un\u2019istituzione giovane, dinamica e con una forte vocazione internazionale, con sede a Milano, in cui formazione medica, ricerca biomedica e pratica clinica sono strettamente integrate. All\u2019interno del Dipartimento di Scienze Biomediche, i forti legami tra l\u2019Universit\u00e0 e l\u2019IRCCS °µÍø½ûÇø Research Hospital creano un ambiente fertile per collaborazioni tra ricerca di base, traslazionale e clinica. In questo contesto, l&#8217;<strong>°µÍø½ûÇø University Biophysics Research Center<\/strong> risponde alla crescente necessit\u00e0 di approcci quantitativi e basati sulla fisica per affrontare sfide biologiche e mediche.<\/p>\n\n\n\n<div style=\height:30px\ aria-hidden=\true\ class=\wp-block-spacer\><\/div>\n\n\n\n<h3 class=\wp-block-heading\>Direttore<\/h3>\n\n\n\n<div class=\hunimed-faculty-member-block wp-block-hunimed-faculty-member\>\n    <div class=\single-member-card\>\n        <div class=\inner\>\n            <div class=\left\>\n\t\t\t\t                    <div class=\member-image\ role=\img\\n                         aria-label=\Photo of Roberto Rusconi\>\n\t\t\t\t\t\t<img loading=\lazy\ decoding=\async\ width=\150\ height=\150\ src=\https:\/\/www.hunimed.eu\/wp-content\/uploads\/2019\/09\/Rusconi-Roberto-7172-150x150.jpg?wsr\ class=\attachment-thumbnail size-thumbnail wp-post-image\ alt=\\ srcset=\https:\/\/www.hunimed.eu\/wp-content\/uploads\/2019\/09\/Rusconi-Roberto-7172-150x150.jpg 150w, https:\/\/www.hunimed.eu\/wp-content\/uploads\/2019\/09\/Rusconi-Roberto-7172-800x800.jpg 800w\ sizes=\auto, (max-width: 150px) 100vw, 150px\ \/>                    <\/div>\n\t\t\t\t            <\/div>\n            <div class=\right\>\n                <h4>Roberto Rusconi<\/h4>\n\n\t\t\t\t                    <span class=\title has-sm-font-size\>\n\t\t\t\t\t\tProfessore Associato\t\t\t\t\t<\/span>\n\t\t\t\t\n\t\t\t\t                    <span class=\tag small\>\n\t\t\t\t\t\tFisica Applicata\t\t\t\t\t<\/span>\n\t\t\t\t                <a class=\view-profile has-s-font-size\\n                   href=\https:\/\/www.hunimed.eu\/it\/member\/roberto-rusconi\/\\n                   rel=\bookmark\>\n\t\t\t\t\tVedi profilo\t\t\t\t\t<svg width=\12\ height=\12\ viewBox=\0 0 12 12\ fill=\none\ xmlns=\http:\/\/www.w3.org\/2000\/svg\>\n    <path d=\M0.666504 5.5H11.3332M11.3332 5.5L7.33317 1.5M11.3332 5.5L7.33317 9.5\ stroke=\currentColor\\n          stroke-width=\1.33333\ stroke-linecap=\round\ stroke-linejoin=\round\\/>\n<\/svg>\n                <\/a>\n            <\/div>\n        <\/div>\n\n    <\/div>\n<\/div>\n\n\n\n<hr class=\wp-block-separator has-alpha-channel-opacity is-style-thin margin-top-xxl margin-bottom-xxl\\/>\n\n\n\n<h3 class=\wp-block-heading\>Aree di ricerca <\/h3>\n\n\n\n<p class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-523004cfeb5aca6ef8d5055fd852c4d8 wp-block-paragraph\>La ricerca del Centro si fonda su competenze consolidate presso °µÍø½ûÇø University in due principali aree: la biofisica dei sistemi microbici e cellulari e gli approcci basati sulla fisica per l\u2019imaging medico. Radicato in questi ambiti di eccellenza, il Centro \u00e8 concepito per evolvere attraverso collaborazioni accademiche, cliniche e industriali, tecnologie emergenti e nuove opportunit\u00e0 scientifiche.<\/p>\n<\/div><\/div>\n\n\n\n<div style=\height:20px\ aria-hidden=\true\ class=\wp-block-spacer\><\/div>\n<\/div><\/div>\n\n\n\n<div class=\wp-block-group alignfull is-style-group-padding-border-top\ id=\faq\><div class=\wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\>\n<div class=\wp-block-group\><div class=\wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\>\n\n<div class=\wp-block-hunimed-notices-block hunimed-notices-block is-style-bg-highlight-without-padding margin-bottom-xxxxxl\ style=\--hunimed-notice-title-bg:#007953;--hunimed-notice-border-color:#007953\><div class=\notice-title\><span class=\notice-title-text\>Biofisica delle interazioni microbiche e cellulari<\/span><\/div><div class=\notice-content\>\n<div class=\wp-block-hunimed-vertical-highlights hunimed-vertical-highlights-block faq-mode is-style-no-margin-border\ data-faq-mode=\true\ data-faq-expand-text=\Show\ data-faq-collapse-text=\Hide\ data-faq-expand-all=\false\ data-faq-initially-expanded=\false\ data-faq-expand-first-item=\true\><div class=\sections-container\>\n<div class=\vertical-highlights-section\ style=\--section-icon-size:24px\><div class=\section-item\><div class=\section-content\><div class=\section-header\><h4>Ambito di ricerca<\/h4><\/div><div class=\content\>\n<p class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-877b245993ccdfa9ad59df2ae591d04f wp-block-paragraph\>Quest\u2019area studia come i principi fisici influenzino il comportamento, l\u2019organizzazione e la ricostruzione funzionale di comunit\u00e0 microbiche, cellule di mammifero e sistemi biochimici cell-free, con particolare attenzione alle interfacce biologiche, materiali e ospite.<\/p>\n<\/div><\/div><\/div><\/div>\n\n\n\n<div class=\vertical-highlights-section\ style=\--section-icon-size:24px\><div class=\section-item\><div class=\section-content\><div class=\section-header\><h4>Attivit\u00e0 in corso<\/h4><\/div><div class=\content\>\n<ul class=\wp-block-list\>\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-04a758d188b54bce49bdcecef2150c77\>Analisi biomeccanica delle risposte microbiche e cellulari alle superfici, incluso il ruolo di flusso, motilit\u00e0, topografia e chimica di superficie nell\u2019adesione batterica, nella formazione di biofilm, nella meccanosensibilit\u00e0 cellulare e nelle infezioni associate a dispositivi medici.<\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-5adbce10e8bbf49cde66a69f5d57fb39\>Studi quantitativi e meccanicistici della dinamica delle popolazioni microbiche, con particolare attenzione a come fisiologia, struttura spaziale, stress, disponibilit\u00e0 di nutrienti e metabolismo microbico influenzino le interazioni ecologiche, la resistenza alla colonizzazione, la risposta agli antibiotici e la comunicazione microbioma\u2013ospite.<\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-3527546674c0e48548b44c8261d7f9b0\>Uso della CLEM per investigare i fenotipi strutturali di materiali e interfacce biologiche o patologiche a livello tissutale, cellulare e molecolare, fornendo informazioni ad alta risoluzione su patogeni, tessuti patologici e formazioni proteiche anomale.<\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-74ab47727922a125e167cf736a36c724\>Assemblaggio bottom-up di sistemi autonomi cell-free capaci di sostenere la propria attivit\u00e0 biochimica attraverso reti metaboliche sintetiche, con l\u2019obiettivo di ingegnerizzare piattaforme terapeutiche avanzate ispirate ai principi fondamentali che governano la vita.<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div>\n\n\n\n<div class=\vertical-highlights-section\ style=\--section-icon-size:24px\><div class=\section-item\><div class=\section-content\><div class=\section-header\><h4>Membri<\/h4><\/div><div class=\content\>\n<ul class=\wp-block-list\>\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-cb08c46b6c24d30712e465cbdfdb4e8a\><a href=\https:\/\/www.humanitas-research.com\/researchers\/edoardo-dimprima\/\>Edoardo D\u2019Imprima<\/a><\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-ded44b02c7b232bbe413aec7a14efe3d\>Simone Giaveri<\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-85f3ffb786967b0c215c3cd35148d4ea\><a href=\https:\/\/www.humanitas-research.com\/researchers\/gabriele-micali\/\>Gabriele Micali<\/a><\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-6969982541e326aba3aa584c03f3975b\><a href=\https:\/\/www.humanitas-research.com\/groups\/roberto-rusconi-group\/\>Roberto Rusconi<\/a><\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n\n<div class=\wp-block-hunimed-notices-block hunimed-notices-block is-style-bg-highlight-without-padding margin-bottom-xxxxxl\ style=\--hunimed-notice-title-bg:#007953;--hunimed-notice-border-color:#007953\><div class=\notice-title\><span class=\notice-title-text\>Fisica e metodi computazionali per l\u2019imaging medico e la radioterapia<\/span><\/div><div class=\notice-content\>\n<div class=\wp-block-hunimed-vertical-highlights hunimed-vertical-highlights-block faq-mode is-style-no-margin-border\ data-faq-mode=\true\ data-faq-expand-text=\Show\ data-faq-collapse-text=\Hide\ data-faq-expand-all=\false\ data-faq-initially-expanded=\false\ data-faq-expand-first-item=\true\><div class=\sections-container\>\n<div class=\vertical-highlights-section\ style=\--section-icon-size:24px\><div class=\section-item\><div class=\section-content\><div class=\section-header\><h4><strong>Ambito di ricerca<\/strong><\/h4><\/div><div class=\content\>\n<p class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-67756150e39f5fb6fcf8d9c129e36ae3 wp-block-paragraph\>Quest\u2019area sviluppa metodi basati sulla fisica e approcci computazionali per estrarre informazioni affidabili e clinicamente rilevanti dalle tecnologie di imaging medico e radioterapia. Combinando imaging quantitativo, modellistica, intelligenza artificiale, analisi delle immagini e pianificazione dei trattamenti, supporta la caratterizzazione in vivo dei processi biologici, la diagnosi e gli interventi guidati dalle immagini, l\u2019ottimizzazione dei trattamenti radioterapici e la medicina di precisione in un\u2019ampia gamma di applicazioni cliniche.<\/p>\n<\/div><\/div><\/div><\/div>\n\n\n\n<div class=\vertical-highlights-section\ style=\--section-icon-size:24px\><div class=\section-item\><div class=\section-content\><div class=\section-header\><h4><strong>Attivit\u00e0 in corso<\/strong><\/h4><\/div><div class=\content\>\n<ul class=\wp-block-list\>\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-1a3207c373b422d69dd94fb70abb581b\>Sviluppo e traslazione clinica di metodologie PET quantitative, integrando imaging dinamico clinicamente sostenibile, modellistica cinetica, radiomica, analisi automatizzata delle immagini e intelligenza artificiale per derivare biomarcatori di imaging per la diagnosi, la caratterizzazione delle lesioni e la valutazione della risposta al trattamento.<\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-aa01b26bfb8bd9b76845cc5746ef1f61\>Sviluppo e traslazione clinica di algoritmi avanzati di analisi delle immagini TC e metodi di caratterizzazione tissutale, includendo acquisizioni ad altissima risoluzione, approcci di ricostruzione spettrale, radiomica, analisi automatizzata delle immagini e intelligenza artificiale, con applicazioni nello sviluppo di biomarcatori di imaging quantitativo per la diagnosi e la valutazione della risposta al trattamento.<\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-060b5fb9e02d3b8eeb360732d000f6bd\>Sviluppo e applicazione di pipeline di analisi delle immagini mediche guidate dall\u2019intelligenza artificiale, basate su machine learning e deep learning, per la segmentazione automatizzata, la caratterizzazione tissutale e l\u2019interpretazione avanzata delle immagini mediche. Questa attivit\u00e0 include l\u2019integrazione di dati multimodali di RM e TC, l\u2019estrazione di biomarcatori quantitativi di imaging clinicamente rilevanti e la progettazione di workflow riproducibili e scalabili per dataset di imaging clinico, inclusa la gestione dei dati DICOM.<\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-f6afa5e556e55a264cc4ef1a7f637f58\>Sviluppo e traslazione clinica di metodologie avanzate di RM quantitativa, integrando RM multiparametrica, modellistica della diffusione, imaging di perfusione, trattografia e analisi quantitativa delle immagini per derivare biomarcatori di microstruttura tissutale, fisiologia vascolare, metabolismo e connettivit\u00e0 strutturale. Le applicazioni attuali includono tumori cerebrali, neurochirurgia funzionale guidata dalle immagini, dolore cronico, malattie infiammatorie intestinali e imaging quantitativo del midollo spinale nella mielopatia cervicale degenerativa.<\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-10101ba60bd2bc1803a602c55f3ff38b\>Sviluppo e applicazione di metodi basati sulla fisica e approcci computazionali per la radioterapia, inclusi ottimizzazione e automazione della pianificazione dei trattamenti, quality assurance, analisi del rischio, radioterapia stereotassica corporea, protonterapia, irradiazione totale del midollo osseo e supporto alle decisioni cliniche assistito dall\u2019intelligenza artificiale.<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div>\n\n\n\n<div class=\vertical-highlights-section\ style=\--section-icon-size:24px\><div class=\section-item\><div class=\section-content\><div class=\section-header\><h4><strong>Membri<\/strong><\/h4><\/div><div class=\content\>\n<ul class=\wp-block-list\>\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-c9124e49114910675f524374a13a63b8\><a href=\https:\/\/www.hunimed.eu\/it\/member\/alessia-artesani\/\>Alessia Artesani<\/a><\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-36bb9234b049119ceb6c9032541965a8\><a href=\https:\/\/www.hunimed.eu\/it\/member\/riccardo-levi\/\>Riccardo Levi<\/a><\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-38ed6447ac3bd5a0a7feaa2eca5ea95b\><a href=\https:\/\/www.hunimed.eu\/it\/member\/pietro-levoni\/\>Pietro Levoni<\/a><\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-66516f4d7c73b5819b447d2f898f1e1b\><a href=\https:\/\/www.hunimed.eu\/it\/member\/pietro-mancosu\/\>Pietro Mancosu<\/a><\/li>\n\n\n\n<li class=\has-grey-dark-color has-text-color has-link-color has-sm-font-size wp-elements-ec83f9a9b7e991480b495e98dbe7f115\><a href=\https:\/\/www.hunimed.eu\/it\/member\/giovanni-savini\/\>Giovanni Savini<\/a><\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n,protected:false},excerpt:{rendered:<p>Biophysics Research Center Based in the Roberto Rocca Innovation Building, the 3D Innovation Lab is a collaborative hub where clinical expertise, scientific research, and academic training converge through the use of advanced 3D printing technologies. 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