{id:91545,date:2026-02-13T14:21:28,date_gmt:2026-02-13T14:21:28,guid:{rendered:https:\/\/www.hunimed.eu\/?post_type=member&#038;p=91545},modified:2026-03-31T15:02:45,modified_gmt:2026-03-31T15:02:45,slug:michela-anna-polidoro,status:publish,type:member,link:https:\/\/www.hunimed.eu\/it\/member\/michela-anna-polidoro\/,title:{rendered:Michela Anna Polidoro},content:{rendered:\n<div class=\wp-block-hunimed-tabs-content hunimed-tabs-content-block\><div class=\tabs-container\>\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Biosketch\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Biosketch<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p><strong>Formazione<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2023: <\/strong>Abilitazione all&#8217;esercizio della professione di Biologo, Universit\u00e0 di Pavia<\/li>\n\n\n\n<li><strong>2019 &#8211; 2023:&nbsp;<\/strong>Executive Ph.D. in Ingegneria Biomedica CUM LAUDE &#8211; MiMic Lab (Politecnico di Milano). Relatore: Prof. Marco Rasponi; Hepatobiliary Immunopathology Laboratory (°µÍø½ûÇø Clinical and Research Hospital). Relatore: Prof. Ana Lleo<\/li>\n<\/ul>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2013 &#8211; 2016: <\/strong>Laurea Magistrale in Biotecnologie Mediche &#8211; (LM-9) D.M. 270\/2004, Universit\u00e0 degli studi de L\u2019Aquila, votazione 110\/110 CUM LAUDE<\/li>\n<\/ul>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2008 &#8211; 2013: <\/strong>Laurea Triennale in Biotecnologie Mediche, Farmaceutiche e Veterinarie &#8211; (L-2) D.M. 509\/1999, Universit\u00e0 degli studi de L\u2019Aquila, votazione 104\/110<\/li>\n<\/ul>\n\n\n\n<p><strong>Incarichi Accademici<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li>Ruolo attuale: Ricercatore a tempo determinato di tipo A (RTD-A), °µÍø½ûÇø University<\/li>\n\n\n\n<li><strong>2024 &#8211; presente: <\/strong>Postdoctoral Researcher, °µÍø½ûÇø Research Hospital, Hepatobiliary Immunopathology Lab, Milano, Italia<\/li>\n<\/ul>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2023 &#8211; 2024:<\/strong>&nbsp;Postdoctoral Researcher, °µÍø½ûÇø University, Precision Medicine Lab, Milano, Italia<\/li>\n<\/ul>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2019 &#8211; 2023: <\/strong>Research Fellow, Politecnico di Milano (Mimic Lab) and °µÍø½ûÇø Research Hospital (Hepatobiliary Immunopathology Lab), Milano, Italia<\/li>\n\n\n\n<li><strong>2022: <\/strong>Visiting Research Fellow, University of Basel, Visceral Surgery and Precision Medicine Research Lab, Basilea, Svizzera<\/li>\n<\/ul>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2017 &#8211; 2019:<\/strong> Research Fellow, °µÍø½ûÇø Research Hospital, Hepatobiliary Immunopathology Lab, Milano, Italia<\/li>\n<\/ul>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2016 &#8211; 2017: <\/strong>Research Fellow, University of L\u2019Aquila, Pituitary Disease Lab, L\u2019Aquila, Italia<\/li>\n<\/ul>\n\n\n\n<p><strong>Affiliazioni<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2019: <\/strong>Membro &#8211; European Association for the Study of the Liver (EASL)&nbsp;&nbsp;&nbsp;<strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <\/strong><\/li>\n\n\n\n<li><strong>2021: <\/strong>Membro &#8211; Associazione Italiana Studio Fegato (AISF)<\/li>\n\n\n\n<li><strong>2024: <\/strong>Membro &#8211; European Organ-on-chip society (EUROoCS)<\/li>\n<\/ul>\n\n\n\n<p><strong>Premi e Riconoscimenti<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2025: <\/strong>PI &#8211; Fondazione Cariplo &#8211; Giovani Ricercatori 2025 Life Science<\/li>\n\n\n\n<li><strong>2025:<\/strong><em> <\/em>PI (Unit 4) &#8211; ERA-NET TRANSCAN-3 Joint Transnational Call 2024<\/li>\n\n\n\n<li><strong>2024:<\/strong> Postdoctoral Fellowship &#8211; Fondazione Umberto Veronesi 2024<\/li>\n\n\n\n<li>Young Investigator Award &#8211; Liver Cancer Summit (EASL &#8211; Edimburgo 2026, Parigi 2025, Rotterdam 2024, Estoril 2023, Praga 2020) e EASL Congress (Londra 2022)<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Ricerca\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Ricerca<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p>Gli interessi di ricerca della Dr.ssa Michela Anna Polidoro si concentrano sulla ricerca traslazionale che integra oncologia molecolare, immunobiologia e ingegneria biomedica, con particolare attenzione ai tumori epatici primitivi, incluso il colangiocarcinoma (CCA). La sua attivit\u00e0 scientifica \u00e8 volta allo studio dei determinanti molecolari della progressione tumorale, tra cui i pathway di segnalazione oncogenica, la riprogrammazione metabolica e le interazioni tumore\u2013sistema immunitario, che contribuiscono all\u2019aggressivit\u00e0 della malattia e alla resistenza alle terapie.<\/p>\n\n\n\n<p>Il suo lavoro combina tecnologie molecolari avanzate e approcci multi-omici per lo studio della biologia tumorale in modelli sperimentali fisiologicamente rilevanti. Durante il dottorato di ricerca ha sviluppato un modello microfluidico 3D organ-on-chip in grado di riprodurre il microambiente tumorale del colangiocarcinoma, consentendo l\u2019analisi delle dinamiche spazio-temporali delle interazioni cellula\u2013cellula e della regolazione di processi biologici complessi. Questa piattaforma supporta la valutazione della risposta ai trattamenti e lo sviluppo di strategie terapeutiche personalizzate.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Pubblicazioni\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Pubblicazioni<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<ol class=\wp-block-list\>\n<li>Palma C, Salehi S, <strong>Polidoro MA<\/strong>, Moretti M, Rasponi M, Lopa S, Occhetta P. A <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/40936111\/\>Compartmentalized Joint-on-chip (JoC) Model to Unravel the Contribution of Cartilage and Synovium to Osteoarthritis Pathogenesis<\/a>. Adv Sci (Weinh). 2025. doi: 10.1002\/advs.202500374.<\/li>\n\n\n\n<li>Milardi G, Franceschini B, Camisaschi C, Puccio S, Costa G, Soldani C, Uva P, Cangelosi D, Carriero R, Lambroia L, Cammarota A, Lodetti-Zangrandi G, Malenica I, Erreni M, Montali I, Lottini T, Raggi C, Kunderfranco P, <strong>Polidoro MA<\/strong>, Aghemo A, Balsano R, Pressiani T, Piscuoglio S, Di Tommaso L, Torzilli G, Rimassa L, Lugli E, Cassani B, Lleo A. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/40889886\/\>Immunosuppressive contribution of tumour-infiltrating B cells in human intrahepatic cholangiocarcinoma and their role in chemoimmunotherapy outcome<\/a>. Gut. 2025. doi: 10.1136\/gutjnl-2025-334861.<\/li>\n\n\n\n<li>Milana F*, <strong>Polidoro MA<\/strong>*, Soldani C, Franceschini B, Famularo S, Di Tommaso L, Terracciano LM, Lleo A, Donadon M, Torzilli G. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/38967502\/\>Unveiling the prognostic role of blood inflammatory indexes in a retrospective cohort of patients undergoing liver resection for intrahepatic cholangiocarcinoma<\/a>. Int J Surg. 2024.* Contributed equally. doi:10.1097\/JS9.0000000000001924.<\/li>\n\n\n\n<li><strong>Polidoro MA<\/strong>, Ferrari E, Soldani C, Franceschini B, Saladino G, Rosina A, Mainardi A, D&#8217;Autilia F, Pugliese N, Costa G, Donadon M, Torzilli G, Marzorati S, Rasponi M, Lleo A. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/38074504\/\>Cholangiocarcinoma-on-a-chip: A human 3D platform for personalised medicine<\/a>. JHEP Rep. 2023. doi: 10.1016\/j.jhepr.2023.100910.<\/li>\n\n\n\n<li>Alvisi G, Termanini A, Soldani C, Portale F, Carriero R, Pilipow K, Costa G, <strong>Polidoro MA<\/strong>, Franceschini B, Malenica I, Puccio S, Lise V, Galletti G, Zanon V, Colombo FS, De Simone G, Tufano M, Aghemo A, Di Tommaso L, Peano C, Cibella J, Iannacone M, Roychoudhuri R, Manzo T, Donadon M, Torzilli G, Kunderfranco P, Di Mitri D, Lugli E, Lleo A. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/35738508\/\>Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target<\/a>. J Hepatol. 2022. doi: 10.1016\/j.jhep.2022.05.043.<\/li>\n<\/ol>\n<\/div><\/div><\/div>\n<\/div><\/div>\n,protected:false},excerpt:{rendered:,protected:false},featured_media:110575,template:,departaments:[287],roles:[214],class_list:[post-91545,member,type-member,status-publish,has-post-thumbnail,hentry,departament-biochimica-2,role-ricercatore-2],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Michela Anna Polidoro - Hunimed<\/title>\n<meta name=\description\ content=\Biosketch Formazione 2023: Abilitazione all&#039;esercizio della professione di Biologo, Universit\u00e0 di Pavia 2019 - 2023:&nbsp;Executive Ph.D. in Ingegneria\ \/>\n<meta name=\robots\ content=\index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\ \/>\n<link rel=\canonical\ href=\https:\/\/www.hunimed.eu\/it\/member\/michela-anna-polidoro\/\ \/>\n<meta property=\og:locale\ content=\it_IT\ \/>\n<meta property=\og:type\ content=\article\ \/>\n<meta property=\og:title\ content=\Michela Anna Polidoro - 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