{id:11727,date:2024-10-17T14:57:51,date_gmt:2024-10-17T14:57:51,guid:{rendered:http:\/\/hunimed-new.local\/Member\/antonietta-franco\/},modified:2026-03-31T10:40:18,modified_gmt:2026-03-31T10:40:18,slug:antonietta-franco,status:publish,type:member,link:https:\/\/www.hunimed.eu\/it\/member\/antonietta-franco\/,title:{rendered:Antonietta Franco},content:{rendered:\n<div class=\wp-block-hunimed-tabs-content hunimed-tabs-content-block\><div class=\tabs-container\>\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Biosketch\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Biosketch<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p class=\wp-block-paragraph\><strong>Formazione<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2013 &#8211; 2016<\/strong>: Dottorato di ricerca, University of Naples Federico II, Naples<\/li>\n\n\n\n<li><strong>2013<\/strong>: Programma estivo di ricerca, GSI Helmholtzzentrum f\u00fcr Schwerionenforschung, Frankfurt<\/li>\n\n\n\n<li><strong>2011<\/strong>: Programma internazionale di scambio per ricercatori, Imperial College London, London (UK)<\/li>\n\n\n\n<li><strong>2016<\/strong>: PhD in Clinical Pathology and Physiology, University of Naples Federico II<\/li>\n\n\n\n<li><strong>2012<\/strong>: Master\u2019s degree in Medical Biotechnology, University of Naples Federico II<\/li>\n\n\n\n<li><strong>2010<\/strong>: Bachelor\u2019s degree in Biotechnology, University of Naples Federico II<\/li>\n<\/ul>\n\n\n\n<p class=\wp-block-paragraph\><strong>Incarichi Accademici<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2024 &#8211; presente<\/strong>: Professore Assistente, °µÍø½ûÇø University, Milano<\/li>\n\n\n\n<li><strong>2019 &#8211; presente<\/strong>: Consulente tecnico, <em>Mitochondria in Motion<\/em>, St. Louis, MO<\/li>\n\n\n\n<li><strong>2019 &#8211; 2023<\/strong>: Istruttore di ricerca, Washington University School of Medicine, St. Louis, MO<\/li>\n\n\n\n<li><strong>2016 &#8211; 2019<\/strong>: Postdoc Research Associate, Pharmacogenomics\/IM Department, Washington University, St. Louis, MO<\/li>\n<\/ul>\n\n\n\n<p class=\wp-block-paragraph\><strong>Premi e Onorificenze<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2018<\/strong>: Finalista O\u2019Leary Competition \u2013 Excellence in Neuroscience, Washington University School of Medicine, St. Louis, MO<\/li>\n\n\n\n<li><strong>2017<\/strong>: McDonnell Center for Cellular and Molecular Neurobiology Postdoctoral Fellowship, Washington University School of Medicine, St. Louis, MO<\/li>\n\n\n\n<li><strong>2016<\/strong>: Postdoctoral Fellowship Societ\u00e0 Italiana Ipertensione Arteriosa (SIIA) \u201cCesare Bartorelli\u201d<\/li>\n\n\n\n<li><strong>2014<\/strong>: Best abstract \u201cHeart Session\u201d, Societ\u00e0 Italiana di Ipertensione Arteriosa (SIIA). Titolo: <em>\u201cIonizing radiation modifies in time dependent manner the subcellular localization of GRK2 in cardiomyocytes\u201d<\/em><\/li>\n\n\n\n<li><strong>2014<\/strong>: Travel Grant FCVB (Frontiers in Cardiovascular Biology), ESC Congress, Barcellona, Spagna<\/li>\n\n\n\n<li><strong>2014<\/strong>: Travel Grant Societ\u00e0 Italiana di Ipertensione Arteriosa (SIIA), Bologna, Italia<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Ricerca\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Ricerca<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p class=\wp-block-paragraph\>L&#8217;obiettivo principale della ricerca della Dott. ssa Franco \u00e8 comprendere il meccanismo molecolare dei mitocondri e la rilevanza clinica nei difetti di fusione mitocondriale collegati ad anomalie cardiache e malattie neurodegenerative. Otto anni fa, quando si \u00e8 impegnata per la prima volta nella ricerca mitocondriale, ha iniziato studiando le disfunzioni ereditarie della fusione mitocondriale nella malattia neurodegenerativa Charcot-Marie-Tooth di tipo 2A (CMT2A). Nel prossimo futuro, lei ha intenzione di continuare a concentrarsi sui difetti ereditari della fusione mitocondriale nelle anomalie cardiache. L&#8217;obiettivo a lungo termine di questo progetto sar\u00e0 trovare modi per affrontare strategie terapeuticamente per il trattamento dei difetti di fusione mitocondriale sia nell&#8217;insufficienza cardiaca che nelle malattie neurologiche. Questa ricerca avr\u00e0 grande rilevanza poich\u00e9 analizzer\u00e0 le varianti umane che inducono malattie ereditarie.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Pubblicazioni\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Pubblicazioni<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<ol class=\wp-block-list\>\n<li><strong>Franco A<\/strong>, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW II. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/27775718\/\>Correcting mitochondrial fusion by manipulating mitofusin conformations<\/a>. Nature. 2016 Dec 1;540 (7631):74-79. doi: 10.1038\/nature20156. Epub 2016 Oct 24. PMID: 27775718<\/li>\n\n\n\n<li>Song M, <strong>Franco A<\/strong>, Fleischer JA, Zhang L, Dorn GW 2nd. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/29107503\/\>Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence<\/a>. Cell Metab. 2017 Dec 5;26(6):872-883.e5. doi: 10.1016\/j.cmet.2017.09.023. Epub 2017 Oct 26.PMID:29107503<\/li>\n\n\n\n<li>Rocha AG(*), <strong>Franco A<\/strong>(*), Krezel AM, Rumsey JM, Alberti JM, Knight WC, Biris N, Zacharioudakis E, Janetka JW, Baloh RH, Kitsis RN, Mochly-Rosen D, Townsend RR, Gavathiotis E, Dorn GW2nd. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/29674596\/\>MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A<\/a>. Science. 2018 Apr 20;360(6386):336- 341doi:10.1126\/science.aao1785. PMID:29674596<\/li>\n\n\n\n<li><strong>Franco A.<\/strong>, Dang X., Walton E., Ho J., Zablocka B., Ly C., Miller T., Baloh R., Shy M., Yoo A., Dorn II GW. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/33074106\/\>Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A Elife<\/a>. 2020 Oct 19;9:e61119. doi: 10.7554\/eLife.61119. Online ahead of print. PMID: 33074106<\/li>\n\n\n\n<li><strong>Franco A.,<\/strong> Li J., Kelly D., Hershberger R., Marian A., Lewis R., Song M., Dang X., D. Schmidt A., Mathyer M. , Edwards R.J. de Guzman Strong C., Dorn II G. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/37910431\/\>A human mitofusin 2 mutation cam cause mitophagic cardiomyopathy<\/a>. (ElifeNov 1, 2023 https:\/\/doi.org\/10.7554\/eLife.84235)<\/li>\n<\/ol>\n<\/div><\/div><\/div>\n<\/div><\/div>\n,protected:false},excerpt:{rendered:,protected:false},featured_media:32822,template:,departaments:[365],roles:[347],class_list:[post-11727,member,type-member,status-publish,has-post-thumbnail,hentry,departament-fisiologia-4,role-ricercatore-3],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Antonietta Franco - Hunimed<\/title>\n<meta name=\description\ content=\Biosketch Formazione 2013 - 2016: Dottorato di ricerca, University of Naples Federico II, Naples 2013: Programma estivo di ricerca, GSI Helmholtzzentrum\ \/>\n<meta name=\robots\ content=\index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\ \/>\n<link rel=\canonical\ href=\https:\/\/www.hunimed.eu\/it\/member\/antonietta-franco\/\ \/>\n<meta property=\og:locale\ content=\it_IT\ \/>\n<meta property=\og:type\ content=\article\ \/>\n<meta property=\og:title\ content=\Antonietta Franco - 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