{id:11681,date:2024-01-15T16:52:09,date_gmt:2024-01-15T16:52:09,guid:{rendered:http:\/\/hunimed-new.local\/Member\/charlotte-k-y-ng-2\/},modified:2026-03-31T14:19:13,modified_gmt:2026-03-31T14:19:13,slug:charlotte-k-y-ng,status:publish,type:member,link:https:\/\/www.hunimed.eu\/it\/member\/charlotte-k-y-ng\/,title:{rendered:Charlotte K. Y. Ng},content:{rendered:\n<div class=\wp-block-hunimed-tabs-content hunimed-tabs-content-block\><div class=\tabs-container\>\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Biosketch\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Biosketch<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p class=\wp-block-paragraph\><strong>Formazione<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2012<\/strong>: Dottorato di ricerca, Universit\u00e0 di Cambridge, Regno Unito<\/li>\n\n\n\n<li><strong>2012<\/strong>: Postdoc, Institute of Cancer Research, Londra, Regno Unito<\/li>\n<\/ul>\n\n\n\n<p class=\wp-block-paragraph\><strong>Incarichi Accademici<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2023 &#8211; presente<\/strong>: Professore Associato, °µÍø½ûÇø University<\/li>\n\n\n\n<li><strong>2019<\/strong>: Avvio del proprio gruppo di ricerca, Universit\u00e0 di Berna, Svizzera<\/li>\n\n\n\n<li><strong>2016 &#8211; 2018<\/strong>: Ricercatrice associata, Universit\u00e0 di Basilea, Svizzera<\/li>\n\n\n\n<li><strong>2013<\/strong>: Trasferimento del laboratorio al Memorial Sloan-Kettering Cancer Center, New York, Stati Uniti<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Ricerca\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Ricerca<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p class=\wp-block-paragraph\>Il lavoro di Charlotte si concentra sull&#8217;utilizzo della multiomica, della bioinformatica e della biologia computazionale nel campo dell&#8217;oncologia di precisione. Con molti anni di esperienza nel lavoro con i dati multiomici, il lavoro di Charlotte punta a sfruttare l&#8217;abbondanza di dati &#8220;omici&#8221; derivati da campioni annotati clinicamente in contesti computazionali per far progredire la nostra comprensione delle dinamiche cellulari tumorali, per scoprire nuovi biomarcatori e bersagli terapeutici e per chiarire le associazioni genotipo-fenotipo nel cancro.\n\nCharlotte durante la sua carriera ha sviluppato pipeline di analisi dei dati di sequenziamento automatizzate e riproducibili, che sono state utilizzate in oltre 60 pubblicazioni di ricerca. Attualmente \u00e8 attiva nel gruppo di lavoro per il coordinamento e la gestione dei dati dell&#8217;International Cancer Genome Consortium (ICGC-ARGO) e ha contribuito ai gruppi di lavoro per la ricerca traslazionale e la medicina personalizzata della European Society for Medical Oncology (ESMO) e al gruppo di lavoro per l&#8217;analisi del Cancer Genome Atlas (TCGA). I suoi attuali progetti di ricerca incorporano la profilazione dell&#8217;espressione genica a singola cellula e della trascrittomica spaziale per comprendere la composizione e la dinamica cellulare dei tumori umani.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Pubblicazioni\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Pubblicazioni<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<ol class=\wp-block-list\>\n<li>Kashani E, Schnidrig D, Gheinani AH, Ninck MS, Zens P, Maragkou T, Baumgartner U, Schucht P, R\u00e4tsch G, Rubin MA, SOCIBP consortium, Berezowska S, <strong>Ng CKY<\/strong>, Vassella E. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/36124685\/\>Integrated longitudinal analysis of adult grade 4 diffuse gliomas with long-term relapse interval revealed upregulation of TGF-\u03b2 signaling in recurrent tumors<\/a>. <em>Neuro-oncol<\/em>. 25(4):662-673 (2023).<\/li>\n\n\n\n<li><strong>Ng CKY<\/strong>, Dazert E, Boldanova T, Coto-Llerena M, Nuciforo S, Ercan C, Suslov A, Meier MA, Bock T, Schmidt A, Ketterer S, Wang X, Wieland S, Matter MS, Colombi M, Piscuoglio S, Terracciano LM, Hall MN, Heim MH. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/35508466\/\>Proteogenomic characterization of hepatocellular carcinoma across etiologies and stages<\/a>. <em>Nature Commun.<\/em> 13(1):2436 (2022).<\/li>\n\n\n\n<li>Montazeri H, Coto-Llerena M, Bianco G, Zangene E, Taha-Mehlitz S, Paradiso V, Srivatsa S, de Weck A, Roma G, Lanzafame M, Bolli M, Beerenwinkel N, von Fl\u00fce M, Terracciano LM, Piscuoglio S, <strong>Ng CKY.<\/strong> <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/34313788\/\>Systematic Identification of Novel Cancer Genes through Analysis of Deep shRNA Perturbation Screens<\/a>. <em>Nucleic Acid Res.<\/em> 49(15):8488-8504 (2021).<\/li>\n\n\n\n<li>Bertucci F*, <strong>Ng CKY*<\/strong>, Patsouris A*, Droin N, Piscuoglio S, Carbuccia N, Soria JC, Dien AT, Adnani Y, Kamal M, Garnier S, Meurice G, Jimenez M, Dogan S, Verret B, Chaffanet M, Bachelot T, Campone M, Lefeuvre C, Bonnefoi H, Dalenc F, Jacquet A, De Filippo MR, Babbar N, Birnbaum D, Filleron T, Le Tourneau C, Andr\u00e9 F. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/31118521\/\>Genomic characterization of metastatic breast cancers<\/a>. 569(7757):560\u2013564 (2019).<\/li>\n\n\n\n<li><strong>Ng CKY<\/strong>, Di Costanzo GG, Tosti N, Paradiso V, Coto-Llerena M, Roscigno G, Perrina V, Quintavalle C, Boldanova T, Wieland S, Marino-Marsilia G, Lanzafame M, Quagliata L, Condorelli G, Matter MS, Tortora R, Heim MH, Terracciano LM, Piscuoglio S. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/29509837\/\>Genetic profiling using plasma-derived cell-free DNA in therapy-na\u00efve hepatocellular carcinoma patients: a pilot study<\/a>. <em>Ann Oncol.<\/em> 29(5):1286\u20131291 (2018).<\/li>\n<\/ol>\n<\/div><\/div><\/div>\n<\/div><\/div>\n,protected:false},excerpt:{rendered:,protected:false},featured_media:32910,template:,departaments:[289,262],roles:[202,212],class_list:[post-11681,member,type-member,status-publish,has-post-thumbnail,hentry,departament-genetica-2,departament-genetica-medica-2,role-associate-professor-it,role-professore-associato-2],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Charlotte K. 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