{id:11645,date:2023-01-12T09:43:40,date_gmt:2023-01-12T09:43:40,guid:{rendered:http:\/\/hunimed-new.local\/Member\/giampaolo-trivellin-2\/},modified:2026-04-02T10:12:31,modified_gmt:2026-04-02T10:12:31,slug:giampaolo-trivellin,status:publish,type:member,link:https:\/\/www.hunimed.eu\/it\/member\/giampaolo-trivellin\/,title:{rendered:Giampaolo Trivellin},content:{rendered:\n<div class=\wp-block-hunimed-tabs-content hunimed-tabs-content-block\><div class=\tabs-container\>\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Biosketch\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Biosketch<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p class=\wp-block-paragraph\><strong>Formazione<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2011<\/strong>: Dottorato in Scienze Mediche, Cliniche e Sperimentali \u2013 Indirizzo: Metodologia Clinica e Scienze Endocrinologiche<\/li>\n\n\n\n<li><strong>2007<\/strong>: Specialistica in Biologia Sanitaria<\/li>\n\n\n\n<li><strong>2005<\/strong>: Triennale Biologia Molecolare<\/li>\n<\/ul>\n\n\n\n<p class=\wp-block-paragraph\><strong>Incarichi Accademici<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2022<\/strong>: Ricercatore, °µÍø½ûÇø Research Hospital, Rozzano<\/li>\n\n\n\n<li><strong>2020 &#8211; 2022<\/strong>: Marie-Curie individual fellowship, °µÍø½ûÇø Research Hospital, Rozzano<\/li>\n\n\n\n<li><strong>2018 &#8211; 2020<\/strong>: Post-Doc, National Institutes of Health (NIH), National Institute of Child Health and Human Development (NICHD), Bethesda, Maryland, Stati Uniti, Laboratorio diretto dal Dott. Constantine Stratakis<\/li>\n\n\n\n<li><strong>2013 &#8211; 2018<\/strong>: Post-Doc, National Institutes of Health (NIH), National Institute of Child Health and Human Development (NICHD), Bethesda, Maryland, Stati Uniti, Laboratorio diretto dal Dott. Constantine Stratakis<\/li>\n\n\n\n<li><strong>2011 &#8211; 2013<\/strong>: Post-Doc, Queen Mary University of London, Dipartimento di Endocrinologia, William Harvey Research Institute, London, Regno Unito, Laboratorio diretto dalla Marta Korbonits<\/li>\n<\/ul>\n\n\n\n<p class=\wp-block-paragraph\><strong>Affiliazioni<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2022<\/strong>: Coordinatore dell\u2019EYRC<\/li>\n\n\n\n<li><strong>2019<\/strong>: Membro del comitato giovani dell\u2019ENEA denominato EYRC (ENEA Young Researchers Committee)<\/li>\n\n\n\n<li><strong>2019<\/strong>: Societ\u00e0 Europea di NeuroEndocrinologia (ENEA)<\/li>\n<\/ul>\n\n\n\n<p class=\wp-block-paragraph\><strong>Premi e Onorificenze<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>2020<\/strong>: Migliore presentazione orale al congresso virtuale ENEA<\/li>\n\n\n\n<li><strong>2016<\/strong>: NIH Fellows Award for Research Excellence (FARE) competition, Bethesda, Stati Uniti<\/li>\n\n\n\n<li><strong>2016<\/strong>: Vincitore della Poster Competition al congresso ENDO, Boston, Stati Uniti<\/li>\n\n\n\n<li><strong>2015<\/strong>: Premio per miglior poster al congresso ENDO, San Diego, Stati Uniti<\/li>\n\n\n\n<li><strong>2011<\/strong>: Association for Multiple Endocrine Neoplasia Disorders (AMEND) Premio giovane ricercatore al congresso BES della Societ\u00e0 Britannica di Endocrinologia, Birmingham, Regno Unito<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Ricerca\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Ricerca<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p class=\wp-block-paragraph\>La mia attivit\u00e0 di ricerca riguarda lo studio dei difetti genetici che causano il gigantismo nei bambini e l&#8217;acromegalia negli adulti. Ho iniziato studiando i difetti genetici nei geni <em>AIP<\/em> e <em>CDKN1B<\/em> durante il mio dottorato di ricerca a Padova, in Italia, nel laboratorio della Prof.ssa Carla Scaroni e ho continuato questa linea di studio durante la mia prima esperienza post-dottorato nel laboratorio della Prof.ssa Marta Korbonits alla Queen Mary University of London, nel Regno Unito.\n\nHo poi continuato la mia formazione post-dottorato nel laboratorio del Dott. Stratakis presso gli NIH (National Institutes of Health), negli Stati Uniti. Nel suo laboratorio, nel 2014 ha identificato un nuovo gene, un GPCR orfano denominato <em>GPR101<\/em>, coinvolto nei casi pi\u00f9 estremi di gigantismo ipofisario ad esordio infantile.\n\nIl mio recente lavoro si \u00e8 concentrato sull&#8217;identificazione dei ligandi GPR101 e sulla comprensione di come questo recettore regola la crescita dei bambini impiegando modelli animali transgenici (topi e zebrafish) e linee cellulari. Il mio obiettivo \u00e8 quello di diventare un ricercatore nel campo dell&#8217;endocrinologia genetica. A tal fine, nel marzo 2020 ho iniziato una fellowship europea Marie Curie presso l\u2019Istituto Clinico °µÍø½ûÇø, a Rozzano, in Italia per stabilire la mia linea di ricerca.\n\nIl mio attuale interesse di ricerca \u00e8 quello di caratterizzare funzionalmente GPR101 sia dissezionando i meccanismi epigenetici che controllano la sua espressione nelle cellule ipofisarie normali e tumorali, sia quantificando a livello di singola cellula gli effetti intracellulari provocati dagli inibitori GPR101 appena scoperti. A dicembre 2022 sono diventato ricercatore a tempo determinato di tipo A presso °µÍø½ûÇø University.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Pubblicazioni\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Pubblicazioni<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<ol class=\wp-block-list\>\n<li><a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/35202564\/\>Duplications disrupt chromatin architecture and rewire GPR101-enhancer communication in X-linked acrogigantism<\/a> Franke M, Daly AF, Palmeira L, Tirosh A, Stigliano A, Trifan E, Faucz FR, Abboud D, Petrossians P, Tena JJ, Vitali E, Lania AG, G\u00f3mez-Skarmeta JL, Beckers A*, Stratakis CA*, <strong>Trivellin G* <\/strong>Am J Hum Genet. 2022 Apr 7;109(4):553-570. doi: 10.1016\/j.ajhg.2022.02.002<\/li>\n\n\n\n<li><a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/33248229\/\>The X-linked acrogigantism-associated gene gpr101 is a regulator of early embryonic development and growth in zebrafish<\/a> <strong>Trivellin G<\/strong>, Tirosh A, Hern\u00e1ndez-Ram\u00edrez LC, et al. Mol Cell Endocrinol. 2021, 520:111091. doi: 10.1016\/j.mce.2020.111091<\/li>\n\n\n\n<li><a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/27282544\/\>Characterization of GPR101 transcript structure and expression patterns<\/a> <strong>Trivellin G<\/strong>, Bjelobaba I, Daly AF, et al. J Mol Endocrinol. 2016 Aug;57(2):97-111. doi: 10.1530\/JME-16-0045<\/li>\n\n\n\n<li><a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/25470569\/\>Gigantism and acromegaly due to Xq26 microduplications and GPR101 defects<\/a> <strong>Trivellin G*<\/strong>, Daly AF*, Faucz FR, et al. N Engl J Med. 2014 Dec 18;371(25):2363-74. doi: 10.1056\/NEJMoa1408028<\/li>\n\n\n\n<li><a href=\https:\/\/journals.physiology.org\/doi\/prev\/20120717-aop\/pdf\/10.1152\/ajpendo.00546.2011\>MicroRNA miR-107 is overexpressed in pituitary adenomas and in vitro inhibits the expression of aryl hydrocarbon receptor-interacting protein (AIP)<\/a> <strong>Trivellin G<\/strong>, Butz H, Delhove J, et al. Am J Physiol Endocrinol Metab. 2012 Sep;303(6):E708-19. doi: 10.1152\/ajpendo.00546.2011<\/li>\n<\/ol>\n<\/div><\/div><\/div>\n<\/div><\/div>\n,protected:false},excerpt:{rendered:,protected:false},featured_media:32951,template:,departaments:[262],roles:[214,347],class_list:[post-11645,member,type-member,status-publish,has-post-thumbnail,hentry,departament-genetica-medica-2,role-ricercatore-2,role-ricercatore-3],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Giampaolo Trivellin - Hunimed<\/title>\n<meta name=\description\ content=\Biosketch Formazione 2011: Dottorato in Scienze Mediche, Cliniche e Sperimentali \u2013 Indirizzo: Metodologia Clinica e Scienze Endocrinologiche 2007:\ \/>\n<meta name=\robots\ content=\index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\ \/>\n<link rel=\canonical\ href=\https:\/\/www.hunimed.eu\/it\/member\/giampaolo-trivellin\/\ \/>\n<meta property=\og:locale\ content=\it_IT\ \/>\n<meta property=\og:type\ content=\article\ \/>\n<meta property=\og:title\ content=\Giampaolo Trivellin - 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