{id:11487,date:2019-11-24T18:50:28,date_gmt:2019-11-24T18:50:28,guid:{rendered:http:\/\/hunimed-new.local\/Member\/carmelo-carlo-stella\/},modified:2026-03-30T12:57:21,modified_gmt:2026-03-30T12:57:21,slug:carmelo-carlo-stella,status:publish,type:member,link:https:\/\/www.hunimed.eu\/it\/member\/carmelo-carlo-stella\/,title:{rendered:Carmelo Carlo-Stella},content:{rendered:\n<div class=\wp-block-hunimed-tabs-content hunimed-tabs-content-block\><div class=\tabs-container\>\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Biosketch\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Biosketch<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p class=\wp-block-paragraph\>Iscritto alla Facolt\u00e0 di Medicina e Chirurgia dell\u2019Universit\u00e0 di Pavia nel 1975, si laurea con Lode nel 1981 e si specializza in Medicina Interna nel 1986.\n\nNel 1993, si specializza in Ematologia all\u2019Universit\u00e0 di Parma.\n\nDal Dicembre 1999 al Giugno 2011, lavora come Dirigente Medico presso la Divisione di Oncoematologia della Fondazione IRCCS Istituto Nazionale Tumori di Milano, dove dal 2005 al 2011 dirige l\u2019Unit\u00e0 di Manipolazione di Cellule Staminali Emopoietiche.\n\nNel 2006, viene chiamato come Professore Associato di Oncologia Medica all\u2019Universit\u00e0 di Milano.\n\nDal Luglio 2011, si trasferisce all\u2019Istituto Clinico °µÍø½ûÇø &#8211; IRCCS, dove attualmente ricopre l\u2019incarico di Capo Sezione di Malattie Linfoidi e Terapie Sperimentali.\n\nDal Gennaio 2017, viene chiamato come Professore Associato di Ematologia all\u2019Universit\u00e0 °µÍø½ûÇø.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Ricerca\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Ricerca<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p class=\wp-block-paragraph\><strong>Ricerca Traslazionale<\/strong><\/p>\n\n\n\n<p class=\wp-block-paragraph\>Svolge attivit\u00e0 di ricerca traslazionale con lo scopo di: (i) sviluppare a livello preclinico e clinico farmaci a bersaglio molecolare e anticorpi monoclonali (non-coniugati, coniugati a farmaci citotossici, bispecifici) per il trattamento di linfomi ricaduti o refrattari; (ii) sviluppare terapie che bersagliano il microambiente tumorale; (iii) ottimizzare la gestione clinica (diagnostica e terapeutica) di pazienti con Linfoma di Hodgkin e Linfoma non-Hodgkin mediante l\u2019analisi del DNA tumorale circolante.<\/p>\n\n\n\n<p class=\wp-block-paragraph\><strong>Ricerca Clinica<\/strong><\/p>\n\n\n\n<p class=\wp-block-paragraph\>E\u2019 investigatore principale o co-investigatore di studi clinici di fase 1 e 2 che hanno come obiettivo quello di sviluppare nuove modalit\u00e0 di immunoterapia antitumorale nei pazienti con Linfoma di Hodgkin, Linfoma non-Hodgkin, Mieloma Multiplo, Leucemia Linfatica Cronica. Al 30 ottobre, 2019, ho pubblicato 245 lavori su riviste peer-reviewed indicizzate da JCR\u00ae con H-index (Google Scholar) di 42.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Pubblicazioni\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Pubblicazioni<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<ol class=\wp-block-list\>\n<li>Reichel J., Chadburn A., Rubinstein P.G., Giulino-Roth L., Tam W., Liu Y., Gaiolla R., Eng K., Brody J., Inghirami G., <strong>Carlo-Stella C.<\/strong>, Santoro A., Rahal D., Totonchy J., Elemento O., Cesarman E., Roshal M.: <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/25488972\/\>Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells<\/a>. <strong><em>Blood<\/em><\/strong><em>125:1061-1072, 2015<\/em><\/li>\n\n\n\n<li>Santoro A., Mazza R., Pulsoni A., Re A., Bonfichi M., Zilioli V.R., Salvi F., Merli F., Anastasia A., Luminari S., Annechini G., Gotti M., Peli A., Liberati A.M., Di Renzo N., Castagna L., Giordano L., <strong>Carlo-Stella C.<\/strong>: <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/27382096\/\>Bendamustine in combination with Gemcitabine and Vinorelbine is an effective regimen as induction chemotherapy before autologous stem-cell transplantation for relapsed or refractory Hodgkin lymphoma: final results of a multicenter phase II study<\/a>. <strong><em>J Clin Oncol<\/em><\/strong><em>34:3293-9, 2016<\/em><\/li>\n\n\n\n<li>Merryman R.W., Kim H.T., Zinzani P.L., <strong>Carlo-Stella C.<\/strong>, Ansell S.M., Perales M.A., Avigdor A., Halwani A.S., Houot R., Marchand T., Dhedin N., Lescaut W., Thiebaut-Bertrand A., Fran\u00e7ois S., Stamatoullas-Bastard A., Rohrlich P-S, Labussi\u00e8re Wallet H., Castagna L., Santoro A., Bachanova V., Bresler S.C., Srivastava A., Kim H., Pesek E., Chammas M., Reynolds C., Ho V.T., Antin J.H., Ritz J., Soiffer R.J., Armand P.: <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/28073785\/\>Safety and Efficacy of Allogeneic Hematopoietic Stem Cell Transplant after PD-1 Blockade in Relapsed\/Refractory Lymphoma<\/a>. <strong><em>Blood<\/em><\/strong><em>129:1380-1388, 2017.<\/em><\/li>\n\n\n\n<li>Spina V., Bruscaggin A., Cuccaro A., Martini M., Di Trani M., Forestieri G., Manzoni M., Condoluci A., Arribas A., Terzi-Di-Bergamo L., Locatelli S.L., Cupelli E., Ceriani L., Moccia A.A., Stathis A., Nassi L., Deambrogi C., Diop F., Guidetti F., Cocomazzi A., Annunziata S., Rufini V., Giordano A., Neri A., Boldorini R., Gerber B., Bertoni F., Ghielmini M., St\u00fcssi G., Santoro A., Cavalli F., Zucca E., Larocca L.M., Gaidano G., Hohaus S.,\u00a0<strong>Carlo-Stella C.<\/strong>, Rossi D: <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/29449275\/\>Circulating tumor DNA reveals genetics, clonal evolution and residual disease in classical Hodgkin lymphoma<\/a>. <strong><em>Blood<\/em><\/strong><em>131:2413-2415, 2018<\/em><\/li>\n\n\n\n<li>Locatelli S.L., Careddu G., Serio S., Consonni F.M., Maeda A., Viswanadha S., Vakkalanka S., Castagna L., Santoro A., Allavena P., Sica A., <strong>Carlo-Stella C.<\/strong>: <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/30352904\/\>Targeting cancer cells and tumor microenvironment in preclinical and clinical models of Hodgkin lymphoma using the dual PI3K\u03b4\/\u03b3 inhibitor RP6530<\/a>. <strong><em>Clin Cancer Res<\/em><\/strong><em>. 25:1098-1112, 2019.<\/em><\/li>\n<\/ol>\n<\/div><\/div><\/div>\n<\/div><\/div>\n,protected:false},excerpt:{rendered:,protected:false},featured_media:32650,template:,departaments:[255,172],roles:[203,206],class_list:[post-11487,member,type-member,status-publish,has-post-thumbnail,hentry,departament-ematologia-2,departament-malattie-del-sangue,role-full-professor-it,role-professore-ordinario],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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