{id:11484,date:2019-12-04T09:16:30,date_gmt:2019-12-04T09:16:30,guid:{rendered:http:\/\/hunimed-new.local\/Member\/maria-rescigno\/},modified:2026-03-31T15:17:24,modified_gmt:2026-03-31T15:17:24,slug:maria-rescigno,status:publish,type:member,link:https:\/\/www.hunimed.eu\/it\/member\/maria-rescigno\/,title:{rendered:Maria Rescigno},content:{rendered:\n<div class=\wp-block-hunimed-tabs-content hunimed-tabs-content-block\><div class=\tabs-container\>\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Biosketch\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Biosketch<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p class=\wp-block-paragraph\>Maria Rescigno si \u00e8 laureata in Biologia nel 1990 all\u2019Universit\u00e0 di Milano. Dal 1991 al 1994 ha lavorato all\u2019Universit\u00e0 di Cambridge, UK, nel Dipartimento di Biochimica come visiting scholar.<\/p>\n\n\n\n<p class=\wp-block-paragraph\>Dal 1995 al 1999, ha lavorato al CNR dove ha conseguito il suo PhD in Farmacologia e Tossicologia nel 1999. Dal 1999 al 2001 Ha lavorato all\u2019Universita\u2019 di Milano-Bicocca dove si e\u2019 specializzata in Biotecnologia applicata. <\/p>\n\n\n\n<p class=\wp-block-paragraph\>Dal 2001 al 2017 \u00e8 stata direttrice dell\u2019Unit\u00e0 di ricerca sulle cellule dendritiche ed immunoterapia nel Dipartimento di Oncologia sperimentale all\u2019Istituto europeo di Oncologia. Ha pubblicato pi\u00f9 di 130 lavori. <\/p>\n\n\n\n<p class=\wp-block-paragraph\>Nel 2008-2013 \u00e8 stata visiting professor all\u2019Universit\u00e0 di Oslo. <\/p>\n\n\n\n<p class=\wp-block-paragraph\>Nel 2016 Maria Rescigno ha fondato Postbiotica una start-up sul microbiota.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Ricerca\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Ricerca<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p class=\wp-block-paragraph\>Il principale campo di ricerca del laboratorio e\u2019 l\u2019immunit\u00e0 delle mucose ed in particolare l\u2019interazione tra l\u2019ospite ed I microorganismi al livello delle superfici mucosali. <\/p>\n\n\n\n<p class=\wp-block-paragraph\>E\u2019 stata la prima a mostrare che le cellule dendritiche partecipano attivamente alla cattura di batteri nell\u2019intestino e il microambiente cellulare controlla l\u2019omeostasi immunitaria. Ha anche dimostrato l\u2019esistenza nell\u2019intestino di una barriera vascolare che ricorda la barriera ematoencefalica e che non permette la disseminazione sistemica dei batteri attraverso il circolo ematico. <\/p>\n\n\n\n<p class=\wp-block-paragraph\>Un altro campo di interesse del laboratorio \u00e8 lo sviluppo di nuovi approcci immunoterapici basati sui batteri come immunostimolanti. Ha dimostrato che I batteri inducono la formazione di giunzioni canale tra cellula tumorale e cellula dendritica per un efficiente attivazione della risposta tumore-specifica. Ha anche sviluppato batteri tumore-specifici che agiscono come missile intelligenti per eliminare solo le cellule tumorali.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Pubblicazioni\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Pubblicazioni<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<ol class=\wp-block-list\>\n<li>Rimoldi, M., Chieppa, M., Salucci, V., Sonzogni, A., Nespoli, A., Viale, G., Allavena, P.,\u00a0<strong>Rescigno, M<\/strong>. <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/15821737\/\>Intestinal immune homeostasis is regulated by the cross-talk between epithelial cells and dendritic cells<\/a>. (2005)\u00a0<strong><em>Nat Immunol<\/em><\/strong><em>.\u00a0<\/em>6:507-14.<\/li>\n\n\n\n<li>Saccheri F, Pozzi C, Avogadri F, Barozzi S, Faretta M, Fusi P,&nbsp;<strong>Rescigno M<\/strong>.&nbsp;<a class=\external\ href=\http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20702856\>Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity<\/a>&nbsp; &nbsp; &nbsp;<strong><em>Sci Transl Med<\/em><\/strong>. 2010 Aug 11;2(44):44ra57.<\/li>\n\n\n\n<li>Spadoni I, Zagato E, Bertocchi A, Paolinelli R, Hot E, Di Sabatino A, Caprioli F, Bottiglieri L, Oldani A, Viale G, Penna G, Dejana E,&nbsp;<strong>Rescigno M<\/strong>.&nbsp;<a class=\external\ href=\http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26564856\>A gut-vascular barrier controls the systemic dissemination of bacteria<\/a>&nbsp; &nbsp; 2015 Nov 13;350(6262):830-4. doi: 10.1126\/science.aad0135.<\/li>\n\n\n\n<li>Guglietta S, Chiavelli A, Zagato E, Krieg C, Gandini S, Ravenda PS, Bazolli B, Lu B, Penna G,&nbsp;<strong>Rescigno<\/strong>&nbsp;<a class=\external\ href=\http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26996437\>Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis<\/a>&nbsp; &nbsp;&nbsp;<strong><em>Nat Commun.<\/em><\/strong>&nbsp;2016 Mar 21;7:11037. doi: 10.1038\/ncomms11037.<\/li>\n\n\n\n<li>Pozzi C, Cuomo A, Spadoni I, Magni E, Silvola A, Conte A, Sigismund S, Ravenda PS, Bonaldi T, Zampino MG, Cancelliere C, Di Fiore PP, Bardelli A, Penna G,&nbsp;<strong>Rescigno M.<\/strong>&nbsp;<a class=\external\ href=\http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27135741\>The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death<\/a>&nbsp; &nbsp; &nbsp;<strong><em>Nat Med.<\/em><\/strong>&nbsp;2016 Jun;22(6):624-31. doi: 10.1038\/nm.4078. Epub 2016 May 2.<\/li>\n<\/ol>\n<\/div><\/div><\/div>\n<\/div><\/div>\n,protected:false},excerpt:{rendered:,protected:false},featured_media:32928,template:,departaments:[354],roles:[203,206],class_list:[post-11484,member,type-member,status-publish,has-post-thumbnail,hentry,departament-patologia-generale-3,role-full-professor-it,role-professore-ordinario],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Maria Rescigno - Hunimed<\/title>\n<meta name=\description\ content=\Biosketch Maria Rescigno si \u00e8 laureata in Biologia nel 1990 all\u2019Universit\u00e0 di Milano. 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