{id:11459,date:2019-09-16T12:35:25,date_gmt:2019-09-16T12:35:25,guid:{rendered:http:\/\/hunimed-new.local\/Member\/antonio-inforzato-2\/},modified:2026-03-31T12:16:39,modified_gmt:2026-03-31T12:16:39,slug:antonio-inforzato,status:publish,type:member,link:https:\/\/www.hunimed.eu\/it\/member\/antonio-inforzato\/,title:{rendered:Antonio Inforzato},content:{rendered:\n<div class=\wp-block-hunimed-tabs-content hunimed-tabs-content-block\><div class=\tabs-container\>\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Biosketch\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Biosketch<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p>Antonio Inforzato ha conseguito la <strong>Laurea in Chimica<\/strong> (indirizzo Biologico) presso l\u2019Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d (2001) ed il <strong>Dottorato in Immunologia<\/strong> presso l\u2019Universit\u00e0 degli Studi di Roma \u201cTor Vergata\u201d (2006). Ha quindi ampliato la propria formazione in <strong>Biochimica<\/strong> e <strong>Biofisica<\/strong> presso la Faculty of Life Sciences, <strong>University of Manchester<\/strong> (Manchester, UK), sotto la supervisione del prof. Anthony J Day (2006-2009). Durante il percorso di dottorato e, successivamente, post-dottorato, ha svolto attivit\u00e0 di ricerca e di studio presso il Leiden University Medical Center (Leiden, The Netherlands; 2005) e la Medical Research Council (MRC) Immunochemistry Unit, University of Oxford (Oxford, UK; 2006). E\u2019 stato destinatario di <strong>fellowships<\/strong> <strong>FIRC<\/strong> (Fondazione Italiana per la Ricerca sul Cancro; 2006-2007), <strong>FHR<\/strong> (Fondazione °µÍø½ûÇø per la Ricerca; 2007), <strong>MRC<\/strong> (2008-2009), <strong>SEMM<\/strong> (European School of Molecular Medicine; 2009-2011) ed <strong>INNOCHEM<\/strong> (Innovative Chemokine-based Therapeutic Strategies for Autoimmunity and Chronic Inflammation; 2010). Recentemente, ha partecipato al Corso di Perfezionamento in \u201c<strong>Epidemiology for Clinical Research<\/strong>\u201d presso °µÍø½ûÇø University (2018). Dal 2009 \u00e8 <strong>Ricercatore<\/strong> presso il <strong>Laboratorio di Immunofarmacologia<\/strong> dell\u2019Istituto Clinico °µÍø½ûÇø, diretto dalla dott.sa Barbara Bottazzi. E\u2019 stato <strong>Ricercatore a Tempo Determinato<\/strong><strong> in Scienze Tecniche di Medicina di Laboratorio<\/strong> (MED\/46) presso l\u2019<strong>Universit\u00e0 degli Studi di Milano<\/strong>. \u00c8 autore di 29 pubblicazioni <em>in extenso<\/em> indicizzate in Pubmed, 2 voci enciclopediche ed 1 capitolo in libro, con impact factor medio superiore a 7,5 ed h-index di 20 (Scopus) e 22 (Google Scholar). E\u2019 co-inventore di 2 brevetti.<\/p>\n\n\n\n<p><strong>Didattica<\/strong><\/p>\n\n\n\n<p>Dal 2016 il dott. Inforzato svolge attivit\u00e0 didattica nell\u2019ambito del corso di Laurea in Medicina e Chirurgia di °µÍø½ûÇø University (fino al 2017 sulla base di accordi convenzionali con l\u2019Universit\u00e0 degli Studi di Milano, presso cui \u00e8 stato Ricercatore a Tempo Determinato, e dal 2018 quale membro della Faculty di °µÍø½ûÇø University), erogando i seguenti insegnamenti:<\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>Biochimica<\/strong> (5 CFU) &#8211; Modulo del corso integrato \u201c<strong>The cell: molecules and processes<\/strong>\u201d (primo anno). In questo modulo vengono presentati gli aspetti principali della biochimica metabolica. Enfasi \u00e8 posta sui meccanismi molecolari che regolano i flussi metabolici intra- ed inter-organo in relazione alla domanda energetica dell\u2019organismo, quale network dinamico di processi biochimici fondamentali.<\/li>\n\n\n\n<li><strong>Biochimica<\/strong> (2 CFU) &#8211; Modulo del corso integrato \u201c<strong>Body at Work 1<\/strong>\u201d (secondo anno). In questo modulo vengono illustrati i processi che sostengono lo sviluppo e la specializzazione di tessuti ed organi, nonch\u00e9 la risposta a stimoli esterni e l\u2019adattamento. Rilievo \u00e8 dato ai meccanismi biochimici alla base della neurotrasmissione, del rimodellamento della matrice extracellulare e del citoscheletro, e delle peculiarit\u00e0 metaboliche di osso, cervello e muscolo.<\/li>\n<\/ul>\n\n\n\n<p>Ad integrazione ed ampliamento della propria offerta formativa, il dott. Inforzato coordina attivit\u00e0 elettive di tipo seminariale (Biochimica della Nutrizione e Sindrome Metabolica) e laboratoriale (Internati su progetti di ricerca <em>ad-hoc<\/em>).<\/p>\n\n\n\n<p><strong>&nbsp;<\/strong><\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Ricerca\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Ricerca<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p>L\u2019attivit\u00e0 scientifica del dott. Antonio Inforzato \u00e8 concentrata sullo <strong>studio della relazione struttura\/funzione di componenti solubili dell\u2019immunit\u00e0 innata in patologie infettive e degenerative, e nell\u2019omeostasi tissutale<\/strong>. Particolare attenzione in tal senso \u00e8 rivolta alla pentrassina lunga <strong>PTX3<\/strong>, quale <strong>paradigma della risposta umorale innata<\/strong>, per cui il dott. Inforzato implementa e coordina le seguenti linee di ricerca:<\/p>\n\n\n\n<ol class=\wp-block-list\>\n<li>caratterizzazione della <strong>struttura di PTX3 e di suoi complessi<\/strong> con proteine del complemento e di matrice;<\/li>\n\n\n\n<li>studio dei meccanismi molecolari sottesi alla <strong>cooperazione funzionale tra pentrassine e sistema del complemento<\/strong> nella risposta immunitaria ad infezioni fungine (aspergillosi invasive) ed in patologie immunodegenerative (degenerazione maculare legata all\u2019et\u00e0);<\/li>\n\n\n\n<li>definizione del ruolo di PTX3 ed altre molecole di matrice (TSG-6, IaI, FGF2) nel <strong>rimodellamento del network extracellulare di acido ialuronico<\/strong> in processi infiammatori (angiogenesi) e pseudo-infiammatori (ovulazione);<\/li>\n\n\n\n<li>individuazione di <strong>nuovi spazi funzionali per gli effettori solubili dell\u2019immunit\u00e0 innata nella fisiologia<\/strong> (mineralizzazione)<strong> e patologia <\/strong>(osteomielite) <strong>dell\u2019osso<\/strong>.<\/li>\n<\/ol>\n\n\n\n<p><strong>&nbsp;<\/strong><\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Pubblicazioni\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Pubblicazioni<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<ol class=\wp-block-list\>\n<li>Gr\u010devi\u0107 D, Sironi M, Valentino S, Deban L, Cvija H, <strong>Inforzato A<\/strong>, Kova\u010di\u0107 N, Katavi\u0107 V, Kelava T, Kalajzi\u0107 I, Mantovani A, Bottazzi B. (2018) <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/29556234\/\>The long pentraxin PTX3 plays a role in bone turnover and repair<\/a>. <em>Front Immunol.<\/em> <strong>9<\/strong>:417 <strong><em>IF: 5.511<\/em><\/strong><\/li>\n\n\n\n<li>Swinkels M, Zhang JH, Tilakaratna V, Black G, Perveen R, McHarg S, <strong>Inforzato A<\/strong>, Day AJ, Clark SJ (2018) <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/29374201\/\>C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation<\/a>. <em>Sci Rep.<\/em> <strong>8<\/strong>(1): 1643 <strong><em>IF: 4.609<\/em><\/strong><\/li>\n\n\n\n<li>Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O, Grube M, L\u00f6ffler J, Maertens JA, Bell AS, <strong>Inforzato A<\/strong>, Barbati E, Almeida B, Santos e Sousa P, Barbui A, Potenza L, Caira M, Rodrigues F, Salvatori G, Pagano L, Luppi M, Mantovani A, Velardi A, Romani L, Carvalho A (2014) <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/24476432\/\>Genetic deficiency of PTX3 and aspergillosis in stem cell transplantation<\/a>. <em>N Engl J Med. <\/em><strong>370<\/strong>(5):421-32<strong><em>IF: 55.873<\/em><\/strong><\/li>\n\n\n\n<li><strong>Inforzato A<\/strong>, Baldock C, Jowitt TA, Holmes DF, Lindstedt R, Marcellini M, Rivieccio V, Briggs DC, Kadler KE, Verdoliva A, Bottazzi B, Mantovani A, Salvatori G, Day AJ (2010) <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/20363749\/\>The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2.<\/a> <em>Biol. Chem. <\/em><strong>285<\/strong>(23):17681-92 <strong><em>IF: 5.328<\/em><\/strong><\/li>\n\n\n\n<li><strong>Inforzato A<\/strong>, Rivieccio V, Morreale AP, Bastone A, Salustri A, Scarchilli L, Verdoliva A, Vincenti S, Gallo G, Chiapparino C, Pacello L, Nucera E, Serlupi-Crescenzi O, Day AJ, Bottazzi B, Mantovani A, De Santis R, Salvatori G (2008) <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/18223257\/\>Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization<\/a>. <em>Biol. Chem.<\/em> <strong>283<\/strong>(15):10147-61 <strong><em>IF: 5.520<\/em><\/strong><\/li>\n<\/ol>\n<\/div><\/div><\/div>\n<\/div><\/div>\n,protected:false},excerpt:{rendered:,protected:false},featured_media:32850,template:,departaments:[336,252],roles:[202,212],class_list:[post-11459,member,type-member,status-publish,has-post-thumbnail,hentry,departament-biochimica-3,departament-biochimica-generale,role-associate-professor-it,role-professore-associato-2],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Antonio Inforzato - Hunimed<\/title>\n<meta name=\description\ content=\Biosketch Antonio Inforzato ha conseguito la Laurea in Chimica (indirizzo Biologico) presso l\u2019Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d (2001) ed il\ \/>\n<meta name=\robots\ content=\index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\ \/>\n<link rel=\canonical\ href=\https:\/\/www.hunimed.eu\/it\/member\/antonio-inforzato\/\ \/>\n<meta property=\og:locale\ content=\it_IT\ \/>\n<meta property=\og:type\ content=\article\ \/>\n<meta property=\og:title\ content=\Antonio Inforzato - 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