{id:11452,date:2019-09-16T14:49:47,date_gmt:2019-09-16T14:49:47,guid:{rendered:http:\/\/hunimed-new.local\/Member\/alberto-mantovani-2\/},modified:2025-08-19T11:04:11,modified_gmt:2025-08-19T11:04:11,slug:alberto-mantovani,status:publish,type:member,link:https:\/\/www.hunimed.eu\/it\/member\/alberto-mantovani\/,title:{rendered:Alberto Mantovani},content:{rendered:\n<div class=\wp-block-hunimed-tabs-content hunimed-tabs-content-block\><div class=\tabs-container\>\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Biosketch\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Biosketch<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n\n<p class=\wp-block-paragraph\><strong>Education<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>1973 <\/strong>M.D., University of Milan, Italy<\/li>\n\n<li><strong>1976 <\/strong>Specialist in Oncology, University of Pavia, Italy<\/li>\n<\/ul>\n\n\n\n<p class=\wp-block-paragraph\><strong>Academic Background<\/strong><\/p>\n\n\n\n<ul class=\wp-block-list\>\n<li><strong>1973-1975 <\/strong>Research assistant Department of Tumor Immunobiology and Chemotherapy, Istituto di Ricerche Farmacologiche \u201cMario\u00a0Negri\u201d, Milan, Italy.<\/li>\n\n<li><strong>1975-1976 <\/strong>Visiting fellow at the Department of Tumor Immunology, Chester Beatty Research Institute, Belmont, Sutton, Surrey, England.<\/li>\n\n<li><strong>1978 and 1979 <\/strong>Visiting fellow at the Laboratory of Immunodiagnosis, NIH, Bethesda, MD., USA, supported by a NATO Grant.<\/li>\n\n<li><strong>1979-1981 <\/strong>Senior investigator, Department of Tumor Immunology and Negri\u201d, Milan, Italy<\/li>\n\n<li><strong>1981-1996 <\/strong>Chief, Laboratory of Immunology, Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d, Milan, Italy.<\/li>\n\n<li><strong>1987 <\/strong>Eleanor Roosvelt UICC Scholar, Laboratory of Molecular Immunoregulation, NIH, Frederick, MD., USA.<\/li>\n\n<li><strong>1994 to 2001 <\/strong>Full Professor of General Pathology, School of Medicine, University of Brescia, Italy.<\/li>\n\n<li><strong>1996 to 2005 <\/strong>Head, Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche \u201cMario Negri\u201d, Milan, Italy.<\/li>\n\n<li><strong>2001 to 2014 <\/strong>Full Professor of General Pathology, School of Medicine, State University\u00a0of Milan, Italy<\/li>\n<\/ul>\n\n<\/div><\/div><\/div>\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Ricerca\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Ricerca<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n\n<ul class=\wp-block-list\>\n<li><strong>Tumor biology.<\/strong>\u00a0 Demonstration in the late \u201870s of the protumor function of tumor-associated macrophages \u00a0(TAM, an acronym now generally used and coined by him in the \u201870s)\u00a0 linking inflammation and cancer (reviewed in Balkwill and Mantovani, Lancet, 2001). TAM as a prototypic M2-like population (Mantovani et al., Nature 2008; Balkwill et al., Cancer Cell 2005).\u00a0 First molecular linking of a genetic event (RET\/PTC rearrangement)\u00a0 causing cancer in humans to the construction of an inflammatory microenvironment (Borrello et al., PNAS 2005). Proof of principle that targeting tumor promoting macrophages has therapeutic value in humans (Germano et al, Cancer Cell 2013). Demonstration that PTX3 is an extrinsic oncosuppressor regulating Complement and macrophage driven tumor promoting inflammation (Bonavita et al Cell 2015). Alberto Mantovani is recognized among his peers as a forerunner in the \u201870s and a \u201cfounding father\u201d of the renaissance of the inflammation-cancer connection.<\/li>\n\n<li><strong>Chemokines.<\/strong>\u00a0Original description and role in TAM recruitment of a unique monocyte attractant, Monocyte Chemotactic\u00a0 Protein-1 (CCL2), as tumor-derived chemotactic factor (Bottazzi et al, Science 1983). Characterization of chemokines and role in pathophysiology, including dendritic cell and polarized T cell migration. Induction of chemokine production by IL-6 in endothelial cells via trans-signaling, a key component of chronic inflammation and cancer (Romano et al, Immunity 1997). Characterization of D6 as a decoy receptor for inflammatory CC chemokines (Mantovani et al, Nature Rev. Immunol 2006). Role of chemokines in carcinogenesis (for a recent contribution Bonavita et al Cell 2015).\u00a0 Role of the chemokines vMIPs in attracting Th2 cells and role of D6 (ACKR2) in Kaposi\u2019s sarcoma.<\/li>\n\n<li><strong>IL-1\/Toll-like receptors (TLR).<\/strong>\u00a0Endothelial cell activation by IL-1 and cytokines (Rossi et al., Science 1985; Bussolino et al, Nature 1989; Romano et al, Immunity 1997). Identification of the type II receptor as a decoy receptor, a novel concept in biology (Colotta et al, Science 1993); the discovery of a decoy receptor represented a paradigm shift after the original definition of the concept of \u201creceptor\u201d by Langley at the 1930\u2019; decoy receptors are now recognized as a general,\u00a0 evolutionary conserved strategy to tune cytokines, chemokines and growth factors. Cloning of an intracellular isoform of the IL-1 receptor antagonist (Muzio et al., J. Exp. Med.\u00a0 1995). First demonstration of MyD88 as the adaptor of mammalian Toll-Like Receptors (TLR) and identification of downstream transducers (Muzio et al., J. Exp. Med. 1998). Cloning and characterization of TIR8\/SIGIRR (IL-1R8), a negative regulator of IL-1 receptor and TLR signalling (Garlanda, et al, Immunity 2013). Role in carcinogenesis.<\/li>\n\n<li><strong>Humoral innate immunity<\/strong>: cloning (cDNA and genomic, mouse and human), structural and functional characterization of the first long pentraxin PTX3 as an IL-1 inducible gene (Garlanda et al, Nature 2002; Jeannin et al, Immunity 2005; Jaillon et al. J. Exp Med 2007\u00a0; Deban et al, Nature Immunol. 2010; Jaillon et al. Immunity 2014; Bonavita et al. Cell 2015); structural immunobiology; role as a paradigm for humoral innate immunity; role as an extrinsic oncosuppresor in murine and human tumors regulating Complement and macrophage driven tumor promoting inflammation (Bonavita et al. Cell 2015); diagnostic and therapeutic translation (Cunha et al New England J. Med. 2014; ongoing). Thus, a regulator of macrophage-driven tumor promoting inflammation is a bona fide cancer gene, silenced in selected human tumors such as colorectal cancer, a finding now independently confirmed.<\/li>\n<\/ul>\n\n<\/div><\/div><\/div>\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Pubblicazioni\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Pubblicazioni<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n\n<p class=\wp-block-paragraph\><strong>Originals<\/strong><\/p>\n\n\n\n<ol class=\wp-block-list\>\n<li>Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, Greco C, Feruglio F, Molgora M, Laface I, Tartari S, Doni A, Pasqualini F, Barbati E, Basso G, Galdiero MR, Nebuloni M, Roncalli M, Colombo PG, Laghi L, Lambris JD, Jaillon S, Garlanda C,\u00a0<strong>Mantovani A. \u2013<em>\u00a0<\/em><\/strong><em>PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.<\/em>\u00a0Cell 160: 700-714, 2015.<\/li>\n<\/ol>\n\n\n\n<p class=\wp-block-paragraph\><strong>Reviews<\/strong><\/p>\n\n\n\n<ol class=\wp-block-list\>\n<li><strong>Mantovani A.<\/strong>, Marchesi F., Laghi L., Malesci A., Allavena P. \u00a0\u2013\u00a0<em>Tumor-associated macrophages as treatment targets in oncology.<\/em>\u00a0Nature Rev, Clin. Oncol.;\u00a0 adv. online publication 2017 doi: 10.1038\/nrclinonc.2016.217<\/li>\n\n<li>Sica A,\u00a0<strong>Mantovani A.<\/strong>\u00a0\u2013\u00a0<em>Macrophage plasticity and polarization: in vivo veritas.<\/em>\u00a0J Clin Invest. 122: 787-795, 2012.<\/li>\n\n<li><strong>Mantovani A<\/strong>, Allavena P, Sica A, Balkwill F \u2013\u00a0<em>Cancer-Related Inflammation.<\/em>\u00a0Nature 454: 436-444, 2008.<\/li>\n\n<li><strong>Mantovani, A.<\/strong>, Romero, P., Paluka, AK., Marincola, FM. \u2013\u00a0<em>Tumor immunity: effector response to tumor and the influence of the microenvironment.<\/em>\u00a0Lancet 371:771-783, 2008.<\/li>\n<\/ol>\n\n<\/div><\/div><\/div>\n<\/div><\/div>\n,protected:false},excerpt:{rendered:,protected:false},featured_media:584,template:,departaments:[351],roles:[352],class_list:[post-11452,member,type-member,status-publish,has-post-thumbnail,hentry,departament-medicina-sperimentale-e-fisiopatologia-4,role-professore-emerito-4],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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