{id:11451,date:2019-09-16T14:54:38,date_gmt:2019-09-16T14:54:38,guid:{rendered:http:\/\/hunimed-new.local\/Member\/michela-matteoli-2\/},modified:2026-03-31T13:47:54,modified_gmt:2026-03-31T13:47:54,slug:michela-matteoli,status:publish,type:member,link:https:\/\/www.hunimed.eu\/it\/member\/michela-matteoli\/,title:{rendered:Michela Matteoli},content:{rendered:\n<div class=\wp-block-hunimed-tabs-content hunimed-tabs-content-block\><div class=\tabs-container\>\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Biosketch\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Biosketch<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p class=\wp-block-paragraph\>Michela Matteoli ha ottenuto il Dottorato di Ricerca presso l\u2019Universit\u00e0 di Pisa nel 1989. <\/p>\n\n\n\n<p class=\wp-block-paragraph\>Dal 1989 al 1991 \u00e8 stata post-doc presso l\u2019Universit\u00e0 di Yale e la University of Virginia School of Medicine. Nel 1992 ha fondato il suo laboratorio al Centro di Farmacologia Cellulare e Molecolare del CNR. <\/p>\n\n\n\n<p class=\wp-block-paragraph\>Nel 2002 \u00e8 diventata Professore Associato di Farmacologia presso l\u2019Universit\u00e0 di Milano e dal 2011 \u00e8 Professore Ordinario. <\/p>\n\n\n\n<p class=\wp-block-paragraph\>Attualmente \u00e8 Direttore del programma di Neuroscienze presso l\u2019Istituto Clinico °µÍø½ûÇø e Professore Ordinario di Farmacologia ad °µÍø½ûÇø University. Ha ottenuto premi allo studio da EMBO e IBRO-MacArthur; nel 2013 ha ricevuto dalla rivista scientifica internazionale Nature il premio Mid Career Nature Mentoring Award e nel 2015 il Premio Atena per i risultati scientifici; \u00e8 membro di EMBO e dell\u2019Academia Europaea per gli straordinari risultati ottenuti; \u00e8 membro del Consiglio della Scuola di Neuroscienze di Parigi, della Fondazione Armenise Harvard, del Centro di Psichiatria e Neuroscienze di INSERM e dell\u2019Universit\u00e0 di Paris-Descartes, di Fondazione Veronesi e Fondazione Volta. <\/p>\n\n\n\n<p class=\wp-block-paragraph\>E\u2019 stata coordinatore o partner in diversi network scientifici internazionali, tra cui NATO, HFSP e EC-FP7. La sua attivit\u00e0 di ricerca \u00e8 finanziata anche da Telethon, Cariplo, Ministero della Salute e Ministero dell\u2019Universit\u00e0 e Ricerca. Matteoli \u00e8 nell\u2019Editorial Board e reviewer ad hoc per diverse riviste scientifiche, tra cui Science, Nature, PNAS, EMBO Journal, Neuron, TINS, Journal of Cell Biology, Journal of Neuroscience. E\u2019 autore di oltre 120 pubblicazioni con un impact factor medio di 7. Il suo H index \u00e8 50 (top Italian scientists).<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Ricerca\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Ricerca<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<p class=\wp-block-paragraph\>Synapses are fundamental brain structures that mediate information transfer between nerve cells; they control all body functions and all aspects of cognition, including attention, perception, learning, decision making, as well as mood and affect. Many psychiatric and neurodegenerative disorders are synaptopathies, i.e. pathological conditions where the molecular and cellular pathways operating at the synapse are dysregulated. Interestingly, inflammation has long-term consequences and could speculatively modify the risk and\/or severity of a variety of brain diseases. Whether inflammation cascades impact synapse formation and function is not completely defined, although a number of molecules involved in inflammatory processes have been found to regulate specific neuronal processes.\n\nMichela Matteoli\u2019s lab\u2019s activity aims at understanding the molecular mechanisms at the basis of synapse dysfunctions in neurodegenerative and psychiatric diseases and at defining how glia-neuron interaction and inflammation impact this processes, in order to identify new targets suitable for therapeutic intervention.<\/p>\n<\/div><\/div><\/div>\n\n\n\n<div class=\wp-block-hunimed-tabs-content-tab tabs-content-tab\><div class=\tab-item\ data-tab-title=\Pubblicazioni\><div class=\tab-header\><button class=\tab-nav\ role=\tab\ aria-selected=\false\><span class=\tab-title\>Pubblicazioni<\/span><\/button><\/div><div class=\tab-content\ role=\tabpanel\ aria-hidden=\true\>\n<ol class=\wp-block-list\>\n<li>Matteo Tamborini , Erica Locatelli, Marco Rasile\u00a0 , Ilaria Monaco , Simona Rodighiero , Irene Corradini ,\u00a0 Mauro Comes Franchini , Lorena Passoni , Michela\u00a0<strong>Matteoli\u00a0<\/strong>\u00a0(2016) <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/26745323\/\>A novel approach combining CTX-nanovectors and low dose radiation to reach infiltrating tumor niches in glioblastoma<\/a> ACS nano in press (IF 12.881)<\/li>\n\n\n\n<li>Joshi P, Turola E, Ruiz A, Bergami A, Libera DD, Benussi L, Giussani P, Magnani G, Comi G, Legname G, Ghidoni R, Furlan R,\u00a0<strong>Matteoli M<\/strong>*, Verderio C. (2014) <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/24336048\/\>Microglia convert aggregated amyloid-\u03b2 into neurotoxic forms through the shedding of microvesicles<\/a>. (*corresponding) Cell Death Differ. 2014 Apr;21(4):582-93. doi: 10.1038\/cdd.2013.180. Epub 2013 Dec 13. (IF 8.385)<\/li>\n\n\n\n<li>(E Menna, S Zambetti, R Morini, Aa Donzelli, D Calvigioni, A Disanza, C, V Cappello, G Fossati, C Regondi, C Frassoni, M Francolini, M Sala, G Scita, M Fahnestock and\u00a0<strong>M Matteoli<\/strong>\u00a0(2013) <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/23685357\/\>Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity<\/a>.. EMBO J 12;32(12):1730-44. (IF 10.748)<\/li>\n\n\n\n<li>Romana Tomasoni, Daniele Repetto, Raffaella Morini, Fabrizio Gardoni, Monica Di Luca, Emilia Turco, Paola Defilippi and\u00a0<strong>Michela Matteoli<\/strong>\u00a0(2013) <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/23868368\/\>SNAP-25 regulates spine formation through postsynaptic binding to p140Cap<\/a> . Nature Comm,\u00a0 19;4:2136. (IF 10.742).<\/li>\n\n\n\n<li>A Senatore, S Colleoni, C Verderio, E Restelli, R Morini, S B. Condliffe, IBertani, S Mantovani, M Canovi, E Micotti, G Forloni, A C. Dolphin,\u00a0<strong>M Matteoli<\/strong>, M Gobbi, and R Chiesa (2012) <a href=\https:\/\/pubmed.ncbi.nlm.nih.gov\/22542184\/\>Mutant Prion Protein Suppresses Glutamatergic Neurotrasmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of Voltage-gated Calcium Channel \u03b1(2)\u03b4-1 Subunit<\/a>. Neuron 26;74(2):300-13. (IF 14.03)<\/li>\n<\/ol>\n<\/div><\/div><\/div>\n<\/div><\/div>\n,protected:false},excerpt:{rendered:,protected:false},featured_media:32591,template:,departaments:[246],roles:[203,206],class_list:[post-11451,member,type-member,status-publish,has-post-thumbnail,hentry,departament-farmacologia,role-full-professor-it,role-professore-ordinario],acf:[],yoast_head:<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Michela Matteoli - Hunimed<\/title>\n<meta name=\description\ content=\Biosketch Michela Matteoli ha ottenuto il Dottorato di Ricerca presso l\u2019Universit\u00e0 di Pisa nel 1989. 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